Calabrò Rocco Salvatore, Gervasi Giuseppe, Bramanti Placido
IRCCS Centro Neurolesi "Bonino-Pulejo".
Acta Biomed. 2014 Dec 17;85(3):222-8.
L-Arginine, a semi-essential cationic amino acid involved in multiple areas of human physiology and metabolism, is a precursor of nitric oxide, and, recently, it has been found to crucially influence endothelial function. Arginine appears to be safe and effective therapy for many health conditions, particularly vascular diseases responsive to modulation of endothelial-derived relaxing factor including intermittent claudication, angina pectoris and erectile dysfunction. However, L-arginine metabolism is still not fully understood, highlighting a complex implication for its pharmacological use in clinical practice. In this review, we want to point out the lights and pitfalls of L-arginine as potential therapeutic option in vascular disorders.
L-精氨酸是一种参与人体生理和代谢多个领域的半必需阳离子氨基酸，是一氧化氮的前体，最近发现它对内皮功能有至关重要的影响。精氨酸似乎对许多健康状况都是安全有效的治疗方法，特别是对那些对内皮源性舒张因子调节有反应的血管疾病，包括间歇性跛行、心绞痛和勃起功能障碍。然而，L-精氨酸的代谢仍未完全了解，这突出了其在临床实践中药理学应用的复杂性。在这篇综述中，我们想指出L-精氨酸作为血管疾病潜在治疗选择的亮点和陷阱。
