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使用荧光可追踪的亚硝酰钌功能纳米平台进行一氧化氮和单线态氧的光控靶向细胞内递送。

Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform.

作者信息

Xiang Hui-Jing, An Lu, Tang Wei-Wei, Yang Shi-Ping, Liu Jin-Gang

机构信息

Key Laboratory for Advanced Materials of MOE & Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China.

出版信息

Chem Commun (Camb). 2015 Feb 14;51(13):2555-8. doi: 10.1039/c4cc09869b.

DOI:10.1039/c4cc09869b
PMID:25567668
Abstract

A multifunctional nitric oxide (NO) delivery nanoplatform that combines functionalities of target directing, fluorescence tracking, and photo-controlled target attacking was developed. The {Ru-NO@TiO2 NPs} nanoplatform selectively targeted folate-receptor over-expressed cancer cells while being simultaneously traced based on its inherent fluorescence. Intracellular localized NO and singlet oxygen were produced on demand by controlled visible light illumination, producing a synergistic cytotoxic effect to cancer cells.

摘要

开发了一种多功能一氧化氮（NO）递送纳米平台，其结合了靶向导向、荧光追踪和光控靶向攻击的功能。{Ru-NO@TiO2 NPs}纳米平台选择性地靶向叶酸受体过表达的癌细胞，同时基于其固有荧光进行追踪。通过可控的可见光照射按需产生细胞内定位的NO和单线态氧，对癌细胞产生协同细胞毒性作用。

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Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform.使用荧光可追踪的亚硝酰钌功能纳米平台进行一氧化氮和单线态氧的光控靶向细胞内递送。
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