Bouvier D P
Madigan Army Medical Center, Department of Medicine, Tacoma, Wash. 98431-5000.
South Med J. 1989 Dec;82(12):1574-6. doi: 10.1097/00007611-198912000-00030.
Hypercalcemia in association with skeletal metastases is common; hypocalcemia in this clinical setting is unexpected, though it has also been described, most commonly with primary lesions of the breast or prostate. In a subset of hypocalcemic patients with breast cancer, there is an inappropriate endocrinologic response as evidenced by a relative hypoparathyroidism and an elevation in the serum level of calcitonin. We have described a representative case and reviewed the literature.
高钙血症伴骨骼转移很常见；在这种临床情况下出现低钙血症则出乎意料，不过也有相关报道，最常见于乳腺或前列腺原发性病变。在一部分低钙血症的乳腺癌患者中，存在不适当的内分泌反应，表现为相对甲状旁腺功能减退和血清降钙素水平升高。我们描述了一个典型病例并回顾了相关文献。
