Liberati A M, Di Costanzo F, Anasetti C, Buzzi F, Falchi R, Grignani F
Tumori. 1983 Jun 30;69(3):223-6. doi: 10.1177/030089168306900309.
A case of humoral non-parathyroid hypercalcemia in a breast cancer patient is discussed. Bone metastases developed 23 months after the first clinical evidence of increased serum calcium levels and did not appear to be etiologically involved in this case of hypercalcemia. Serum levels of I-PTH and PGE2 were normal, as were urinary c-AMP levels. Furthermore, no significant response to corticosteroid therapy was observed. However, the correlation between the activity of metastatic disease and calcemia suggests that this cancer produced humoral factor(s) with calcium-mobilizing activity.
本文讨论了一例乳腺癌患者发生的体液性非甲状旁腺性高钙血症。在首次出现血清钙水平升高的临床证据23个月后发生了骨转移，且在该例高钙血症中骨转移似乎与病因无关。血清I-PTH和PGE2水平正常，尿c-AMP水平也正常。此外，未观察到对皮质类固醇治疗有明显反应。然而，转移性疾病活动与血钙之间的相关性表明，该癌症产生了具有钙动员活性的体液因子。
