艾乐替尼在一名克唑替尼治疗进展且伴有弥漫性软脑膜癌病的ALK阳性非小细胞肺癌患者中诱导出持久（>15个月）的完全缓解。
Alectinib induces a durable (>15 months) complete response in an ALK-positive non-small cell lung cancer patient who progressed on crizotinib with diffuse leptomeningeal carcinomatosis.
作者信息
Ou Sai-Hong Ignatius, Sommers Karen R, Azada Michele C, Garon Edward B
机构信息
Chao Family Comprehensive Cancer Center, Department of Medicine, Division of Hematology-Oncology, University of California Irvine School of Medicine, Orange, California, USA.
Jonsson Comprehensive Cancer Center, Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles School of Medicine, Los Angeles, California, USA.
出版信息
Oncologist. 2015 Feb;20(2):224-6. doi: 10.1634/theoncologist.2014-0309. Epub 2015 Jan 7.
Abstract
This report describes a patient with -rearranged non-small cell lung cancer who developed diffuse leptomeningeal carcinomatosis as the only “site” of progression after a prolonged response to crizotinib and who has been treated successfully with a second-generation ALK inhibitor alone for >15 months.
摘要
本报告描述了一名患有重排非小细胞肺癌的患者，该患者在对克唑替尼产生长时间反应后，出现弥漫性软脑膜癌病作为唯一的进展“部位”，并且仅使用第二代ALK抑制剂成功治疗了超过15个月。
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本文引用的文献
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Alectinib salvages CNS relapses in ALK-positive lung cancer patients previously treated with crizotinib and ceritinib.阿来替尼可挽救先前接受过克唑替尼和色瑞替尼治疗的ALK阳性肺癌患者的中枢神经系统复发。
J Thorac Oncol. 2015 Feb;10(2):232-6. doi: 10.1097/JTO.0000000000000455.
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First-line crizotinib versus chemotherapy in ALK-positive lung cancer.克唑替尼对比化疗用于治疗 ALK 阳性肺癌。
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ALK inhibitors in non-small cell lung cancer: crizotinib and beyond.非小细胞肺癌中的ALK抑制剂：克唑替尼及其他。
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Lancet Oncol. 2014 Sep;15(10):1119-28. doi: 10.1016/S1470-2045(14)70362-6. Epub 2014 Aug 18.
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Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC.ALK 阳性 NSCLC 患者初始疾病进展后继续使用克唑替尼抑制 ALK 带来的临床获益。
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