Kocsis G, McCulloch T A, Thyagarajan D, Wallace W A
Shoulder and Elbow Unit, Nottingham University Hospitals, 69 Bargate, Grimsby, DN34 5BD, Nottingham, UK.
Department of Histopathology, City Campus, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK.
Bone Joint J. 2015 Jan;97-B(1):83-8. doi: 10.1302/0301-620X.97B1.34357.
The LockDown device (previously called Surgilig) is a braided polyester mesh which is mostly used to reconstruct the dislocated acromioclavicular joint. More than 11,000 have been implanted worldwide. Little is known about the tissue reaction to the device nor to its wear products when implanted in an extra-articular site in humans. This is of importance as an adverse immunological reaction could result in osteolysis or damage to the local tissues, thereby affecting the longevity of the implant. We analysed the histology of five LockDown implants retrieved from five patients over the last seven years by one of the senior authors. Routine analysis was carried out in all five cases and immunohistochemistry in one. The LockDown device acts as a scaffold for connective tissue which forms an investing fibrous pseudoligament. The immunological response at the histological level seems favourable with a limited histiocytic and giant cell response to micron-sized wear particles. The connective tissue envelope around the implant is less organised than a native ligament.
锁定装置（以前称为Surgilig）是一种编织聚酯网，主要用于重建脱位的肩锁关节。全球已植入超过11000个。对于该装置植入人体关节外部位时，其组织反应以及磨损产物的组织反应了解甚少。这一点很重要，因为不良免疫反应可能导致骨质溶解或局部组织损伤，从而影响植入物的使用寿命。我们分析了过去七年中由一位资深作者从五名患者身上取出的五个锁定装置植入物的组织学情况。对所有五例进行了常规分析，其中一例进行了免疫组织化学分析。锁定装置作为结缔组织的支架，形成包裹性纤维假韧带。组织学水平的免疫反应似乎良好，对微米级磨损颗粒的组织细胞和巨细胞反应有限。植入物周围的结缔组织包膜不如天然韧带组织有序。
