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科索沃多发性硬化症患者的流行病学特征及功能残疾情况

Epidemiological characteristics and functional disability of multiple sclerosis patients in kosovo.

作者信息

Zeqiraj Kamber, Kruja Jera, Kabashi Serbeze, Muçaj Sefedin

机构信息

Clinic of Neurology, University Clinical Centre, Prishtina, Kosovo.

University Clinical Centre "Mother Therese", Tirana, Albania.

出版信息

Med Arch. 2014 Jun;68(3):178-81. doi: 10.5455/medarh.2014.68.178-181. Epub 2014 May 31.

DOI:10.5455/medarh.2014.68.178-181
PMID:25568528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4240334/
Abstract

BACKGROUND AND OBJECTIVES

Multiple Sclerosis (MS) is a chronic recurrent neurological disease that affects the Central Nervous System. This study aims to determine epidemiological factors that affect the appearance of MS, such as: incidence, prevalence, mortality, case appearance in accordance with the disease phase RRMS, SPMS, PPMS, gender, age, age group, and EDSS.

MATERIALS AND METHODS

Deals with analyzing diagnosed and treated patients in the Clinic of Neurology in Prishtina during the period of 2003-2012. The research was conducted through a questionnaire applied in the diagnosed cases of MS. Information on patients was gathered from: history of illness, discharge reports and other relevant documents on MS illness. Clinical and epidemiological-descriptive study methods were used. The acquired results are shown through tables, graphics. Statistical processing was conducted with Microsoft Office Excel.

RESULTS

From the total number of doubtful hospitalized cases of demyelinization (644) in the Clinic of Neurology in Prishtina, 412 cases (64%) were diagnosed with MS. For the period of 2003-2012 the prevalence of MS has been 19.6 of patients in 100,000 inhabitants. MS incidence rate was 0.95 of patients in 100,000 inhabitants. MS mortality rate was 0.14 of deceased in 100,000 inhabitants. The ratio female - male is 2.3:1. A larger number of patients fall within the age group of 30-39 years-old. Clinical form trends: RRSM 72.3%, SPSM 22.6%, PPSM 5.1%. The rate of EDSS 78.3% (0-3.5), 14.9% (4-6.5), 6.8% (7-9).

摘要

背景与目的

多发性硬化症(MS)是一种影响中枢神经系统的慢性复发性神经疾病。本研究旨在确定影响MS发病的流行病学因素,如:发病率、患病率、死亡率、根据疾病阶段(复发缓解型多发性硬化症RRMS、继发进展型多发性硬化症SPMS、原发进展型多发性硬化症PPMS)的病例出现情况、性别、年龄、年龄组以及扩展残疾状态量表(EDSS)。

材料与方法

对2003年至2012年期间在普里什蒂纳神经病学诊所诊断和治疗的患者进行分析。该研究通过应用于MS确诊病例的问卷进行。患者信息收集自:病史、出院报告及其他有关MS疾病的相关文件。采用临床和流行病学描述性研究方法。所得结果通过表格、图表展示。使用Microsoft Office Excel进行统计处理。

结果

在普里什蒂纳神经病学诊所644例疑似脱髓鞘住院病例中,412例(64%)被诊断为MS。2003年至2012年期间,MS患病率为每10万居民中有19.6例患者。MS发病率为每10万居民中有0.95例患者。MS死亡率为每10万居民中有0.14例死亡。女性与男性比例为2.3:1。更多患者年龄在30 - 39岁年龄组。临床形式趋势:复发缓解型多发性硬化症(RRSM)72.3%,继发进展型多发性硬化症(SPSM)22.6%,原发进展型多发性硬化症(PPSM)5.1%。扩展残疾状态量表(EDSS)评分比例为:78.3%(0 - 3.5),14.9%(4 - 6.5),6.8%(7 - 9)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c936/4240334/9a05494d41a6/MA-68-178-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c936/4240334/8989def16571/MA-68-178-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c936/4240334/9a05494d41a6/MA-68-178-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c936/4240334/8989def16571/MA-68-178-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c936/4240334/9a05494d41a6/MA-68-178-g003.jpg

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