Omerbegović Meldijana
Clinic of Anaesthesia, Resuscitation and Intensive Care, University Clinical Centre Sarajevo, Bosnia and Herzegovina.
Med Arch. 2014 Aug;68(4):268-71. doi: 10.5455/medarh.2014.68.268-271. Epub 2014 Jul 31.
Heart rate variability which denotes variations of the length of consecutive heart cycles has been suggested to reflect the modulation of heart rate by autonomic nervous system.
Sixty four patients of ASA I and ASA II status scheduled for elective abdominal surgical procedures were randomly allocated to group 1 and group 2. Premedication and induction of anaesthesia were performed with same agents. After orotracheal intubation maintenance of balanced anaesthesia was based on administration of same induction agents,opioids and muscle relaxant while delivery of gaseous mixture with sevoflurane in the group 1 (n=32) and isoflurane in the group 2(n=32). Haemodynamic parameters were monitored in perioperative and electrocardiogram was recorded by holter ECG recorder, while the analysis of the parameters were performed by corresponding softwares . Data were presented as mean values of logarithmic (natural logarithm) values of the power of the total spectrum of heart rate variability(TP), mean values of the logarithmic values of low frequency band (LF), mean values of the logarithmic values of high frequency range(HF), and mean values of SD1 and SD2 parameters.
Analysis of the values of hemodynamic parameters has shown changes of haemodynamic parameters during perioperative period without significant statistical differences between the groups. Analysis of the logarhitmic values of parameters of heart rate variability of frequency domain has shown changes of the total spectrum power and LF and HF spestra with variations of the values of total power spectrum and individual components of the spectrum of heart rate variability during the balanced anaesthesia with administration of two different inhalation anaesthetics, without statistically significant differences between the groups.
The results have shown that during balanced anaesthesia with two different inhalation anaesthetics there are variations of haemodynamic variables and parameters of heart rate variability without statistically significance that could show the difference between the groups and different agents administered.
心率变异性指连续心动周期长度的变化，被认为可反映自主神经系统对心率的调节。
64例拟行择期腹部手术的ASA I级和ASA II级患者被随机分为1组和2组。两组患者的术前用药和麻醉诱导采用相同药物。经口气管插管后，两组均使用与诱导相同的药物、阿片类药物和肌肉松弛剂维持平衡麻醉，1组（n = 32）吸入七氟醚，2组（n = 32）吸入异氟醚。围术期监测血流动力学参数，通过动态心电图记录仪记录心电图，并用相应软件分析参数。数据以心率变异性总谱功率（TP）对数（自然对数）值的平均值、低频带（LF）对数均值、高频范围（HF）对数均值以及SD1和SD2参数均值表示。
血流动力学参数值分析显示围术期血流动力学参数有变化，但两组间无显著统计学差异。频域心率变异性参数对数分析显示，在使用两种不同吸入麻醉药维持平衡麻醉期间，心率变异性总谱功率及LF和HF谱随总功率谱值及心率变异性谱各分量值的变化而变化，两组间无统计学显著差异。
结果表明，在使用两种不同吸入麻醉药维持平衡麻醉期间，血流动力学变量和心率变异性参数有变化，但无统计学显著性差异，无法显示两组及所用不同药物之间的差异。
