基于苯并咪唑的抗增殖剂构效关系的初步评估
A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents.
作者信息
Winfield Leyte L, Smith Dayle M, Halemano Kalani, Leggett Carmine S
机构信息
Department of Chemistry, Spelman College, Atlanta, GA 30314, USA.
Department of Physics, Whitman College, Walla Walla, WA 99362, USA.
出版信息
Lett Drug Des Discov. 2008;5(6):369-376. doi: 10.2174/157018008785777324#sthash.5mpkAcrR.dpuf.
Abstract
PDK1 is pivotal in the development and progression of several cancers. A 3D pharmacophore was developed for pyrazole derivatives displaying anti-proliferative activity and PDK1 inhibition. The pharmacophore was utilized in the design of benzimidazole analogs. Our preliminary results indicate the pharmacophore should be useful in designing PDK1 inhibitors and anti-proliferative agents.
摘要
丙酮酸脱氢酶激酶1（PDK1）在多种癌症的发生和发展过程中起关键作用。针对具有抗增殖活性和PDK1抑制作用的吡唑衍生物开发了一种三维药效团。该药效团被用于苯并咪唑类似物的设计。我们的初步结果表明，该药效团在设计PDK1抑制剂和抗增殖剂方面应具有实用性。
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