Faculty of Pharmacy, , Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi, India.
Arch Pharm (Weinheim). 2017 Jun;350(6). doi: 10.1002/ardp.201700040. Epub 2017 May 22.
Cancer, also known as malignant neoplasm, is a dreadful disease which involves abnormal cell growth having the potential to invade or spread to other parts of the body. Benzimidazole is an organic compound that is heterocyclic and aromatic in nature. It is a bicyclic compound formed by the fusion of the benzene and imidazole ring systems. It is an important pharmacophore and a privileged structure in medicinal chemistry. According to the World Health Organisation (2015 survey), one in six deaths is due to cancer around the globe, accounting for 8.8 million deaths of which 70% of the cases were from low- and middle-income countries. In the efforts to develop suitable anticancer drugs, medicinal chemists have focussed on benzimidazole derivatives. This review article covers the current development of benzimidazole-based anticancer agents along with the synthetic approaches and structure-activity relationships (SAR).
癌症，亦称恶性肿瘤，是一种可怕的疾病，涉及异常细胞生长，具有侵犯或扩散到身体其他部位的潜力。苯并咪唑是一种有机化合物，具有杂环和芳香族性质。它是由苯和咪唑环系统融合形成的双环化合物。它是一个重要的药效团和药物化学中的特权结构。根据世界卫生组织（2015 年调查），全球每六个人死亡就有一个归因于癌症，占 880 万人死亡，其中 70%的病例来自中低收入国家。在开发合适的抗癌药物的努力中，药物化学家专注于苯并咪唑衍生物。本文综述了基于苯并咪唑的抗癌药物的最新发展情况，以及它们的合成方法和构效关系（SAR）。
