Fornasari Diego
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Clin Cases Miner Bone Metab. 2014 Sep;11(3):165-8.
The incidence of chronic pain is estimated to be 20-25% worldwide. Although major improvements in pain control have been obtained, more than 50% of the patients reports inadequate relief. It is accepted that chronic pain, if not adequately and rapidly treated, can become a disease in itself, often intractable and maybe irreversible. This is mainly due to neuroplasticity of pain pathways. In the present review I will discuss about pain depicting the rational for the principal pharmacological interventions and finally focusing on opioids, that represent a primary class of drug to treat pain.
据估计，全球慢性疼痛的发病率为20%-25%。尽管在疼痛控制方面已取得重大进展，但仍有超过50%的患者表示疼痛缓解不充分。人们公认，如果慢性疼痛得不到充分、迅速的治疗，其本身可能会成为一种疾病，往往难以治愈，甚至可能不可逆转。这主要是由于疼痛通路的神经可塑性。在本综述中，我将讨论疼痛，阐述主要药物干预措施的原理，最后聚焦于阿片类药物，其是治疗疼痛的一类主要药物。
