McGillicuddy John W, Villar Juan José E, Rohan Vinayak S, Bazaz Sapna, Taber David J, Pilch Nicole A, Baliga Prabhakar K, Chavin Kenneth D
Department of Surgery, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Am Surg. 2015 Jan;81(1):52-5.
Laparoscopic cholecystectomy is the gold standard treatment for the vast majority of patients with symptomatic cholelithiasis. Although cirrhotic patients are twice as likely to develop gallstones as compared with noncirrhotic patients, cirrhosis has historically been considered a relative, if not absolute, contraindication to laparoscopic cholecystectomy. More recently a number of authors have reported on the safety of laparoscopic cholecystectomy in cirrhotic patients. We reviewed our patients retrospectively and assessed the safety of laparoscopic cholecystectomy in cirrhotic patients as compared with noncirrhotics at a large liver transplant center. A retrospective longitudinal cohort study was conducted of all laparoscopic cholecystectomies performed by our surgical group between August 2002 and April 2011. Of 63 patients undergoing laparoscopic cholecystectomy, 32 (51%) were cirrhotic. Of the 30 for whom a Child score could be calculated, 11 (34%) were Child A, 14 (44%) were Child B, and five (16%) were Child C. The morbidity rate was 33 per cent and mortality rate was 2 per cent. Length of stay, conversion rates, 30-day readmission rates, and morbidity and mortality rates were not significantly different between the cirrhotic and noncirrhotic groups. There was a trend toward higher complication rates in Child C cirrhotics. Our results indicate that laparoscopic cholecystectomy can be performed with acceptable morbidity and mortality in carefully selected cirrhotic patients.
腹腔镜胆囊切除术是绝大多数有症状胆结石患者的金标准治疗方法。尽管肝硬化患者患胆结石的可能性是非肝硬化患者的两倍,但从历史上看,肝硬化一直被视为腹腔镜胆囊切除术的相对禁忌症,即使不是绝对禁忌症。最近,一些作者报道了腹腔镜胆囊切除术在肝硬化患者中的安全性。我们对患者进行了回顾性研究,并在一个大型肝移植中心评估了肝硬化患者与非肝硬化患者相比腹腔镜胆囊切除术的安全性。对我们手术团队在2002年8月至2011年4月期间进行的所有腹腔镜胆囊切除术进行了回顾性纵向队列研究。在63例行腹腔镜胆囊切除术的患者中,32例(51%)为肝硬化患者。在可计算Child评分的30例患者中,11例(34%)为Child A级,14例(44%)为Child B级,5例(16%)为Child C级。发病率为33%,死亡率为2%。肝硬化组和非肝硬化组在住院时间、中转率、30天再入院率以及发病率和死亡率方面无显著差异。Child C级肝硬化患者的并发症发生率有升高趋势。我们的结果表明,在精心挑选的肝硬化患者中,腹腔镜胆囊切除术的发病率和死亡率是可以接受的。