一项边缘区淋巴瘤的全基因组关联研究显示与HLA区域有关联。
A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
作者信息
Vijai Joseph, Wang Zhaoming, Berndt Sonja I, Skibola Christine F, Slager Susan L, de Sanjose Silvia, Melbye Mads, Glimelius Bengt, Bracci Paige M, Conde Lucia, Birmann Brenda M, Wang Sophia S, Brooks-Wilson Angela R, Lan Qing, de Bakker Paul I W, Vermeulen Roel C H, Portlock Carol, Ansell Stephen M, Link Brian K, Riby Jacques, North Kari E, Gu Jian, Hjalgrim Henrik, Cozen Wendy, Becker Nikolaus, Teras Lauren R, Spinelli John J, Turner Jenny, Zhang Yawei, Purdue Mark P, Giles Graham G, Kelly Rachel S, Zeleniuch-Jacquotte Anne, Ennas Maria Grazia, Monnereau Alain, Bertrand Kimberly A, Albanes Demetrius, Lightfoot Tracy, Yeager Meredith, Chung Charles C, Burdett Laurie, Hutchinson Amy, Lawrence Charles, Montalvan Rebecca, Liang Liming, Huang Jinyan, Ma Baoshan, Villano Danylo J, Maria Ann, Corines Marina, Thomas Tinu, Novak Anne J, Dogan Ahmet, Liebow Mark, Thompson Carrie A, Witzig Thomas E, Habermann Thomas M, Weiner George J, Smith Martyn T, Holly Elizabeth A, Jackson Rebecca D, Tinker Lesley F, Ye Yuanqing, Adami Hans-Olov, Smedby Karin E, De Roos Anneclaire J, Hartge Patricia, Morton Lindsay M, Severson Richard K, Benavente Yolanda, Boffetta Paolo, Brennan Paul, Foretova Lenka, Maynadie Marc, McKay James, Staines Anthony, Diver W Ryan, Vajdic Claire M, Armstrong Bruce K, Kricker Anne, Zheng Tongzhang, Holford Theodore R, Severi Gianluca, Vineis Paolo, Ferri Giovanni M, Ricco Rosalia, Miligi Lucia, Clavel Jacqueline, Giovannucci Edward, Kraft Peter, Virtamo Jarmo, Smith Alex, Kane Eleanor, Roman Eve, Chiu Brian C H, Fraumeni Joseph F, Wu Xifeng, Cerhan James R, Offit Kenneth, Chanock Stephen J, Rothman Nathaniel, Nieters Alexandra
机构信息
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
出版信息
Nat Commun. 2015 Jan 8;6:5751. doi: 10.1038/ncomms6751.
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
边缘区淋巴瘤（MZL）是B细胞非霍奇金淋巴瘤的第三大常见亚型。我们对1281例欧洲血统的MZL病例和7127例对照进行了两阶段全基因组关联研究（GWAS），并在HLA区域确定了两个与MZL风险显著相关的独立位点，分别位于BTNL2附近（rs9461741，P = 3.95×10^(-15)）和HLA - B附近（rs2922994，P = 2.43×10^(-9)）。这是主要组织相容性复合体中的基因变异影响MZL易感性的首个证据。
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