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Incidence of human T cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in a long-term prospective cohort study of initially asymptomatic individuals in Brazil.在巴西对最初无症状个体进行的长期前瞻性队列研究中，1型人类嗜T细胞病毒相关脊髓病/热带痉挛性截瘫的发病率
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2
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3
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环孢素治疗人嗜T淋巴细胞病毒1型所致的热带痉挛性截瘫/脊髓病：1例报告经验

Cyclosporine for the treatment of HLTV-1-induced HAM/TSP: an experience from a case report.

作者信息

Sánchez-Montalvá Adrián, Salvador Fernando, Caballero Estrella, Molina Israel

机构信息

From the Infectious Diseases Department (AS-M, FS, IM), PROSICS (International Health Program of the Catalan Health Institute), Vall d'Hebron University Hospital, Universitat Autonòma de Barcelona, Barcelona, Spain; and Microbiology Department (EC), Vall d'Hebron Universitary Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.

出版信息

Medicine (Baltimore). 2015 Jan;94(1):e382. doi: 10.1097/MD.0000000000000382.

DOI:10.1097/MD.0000000000000382
PMID:25569667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4602838/
Abstract

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) remains a challenging disease. Treatment options are scarce, and their safety and efficacy are currently a matter of concern.We present a case report describing our experience using cyclosporine in a patient with early HAM/TSP who started with a gait disturbance at Vall d'Hebron University Hospital (Barcelona) from August 2012 to October 2013. After 62 weeks of treatment, clinical improvement was observed and proviral load diminished. No safety concerns were observed.Cyclosporine seems to be effective in new-onset HAM/TSP or in chronic HAM/TSP that develops a relapse. However, the duration and safety profile of this steroid-sparing therapy remain unknown and should be further investigated.

摘要

人类嗜T淋巴细胞病毒1型相关脊髓病/热带痉挛性截瘫（HAM/TSP）仍然是一种具有挑战性的疾病。治疗选择有限，其安全性和有效性目前备受关注。我们报告一例病例，描述了我们在2012年8月至2013年10月期间，在巴塞罗那的瓦尔德希伯伦大学医院对一名患有早期HAM/TSP且以步态障碍起病的患者使用环孢素的经验。经过62周的治疗，观察到临床症状改善且前病毒载量降低。未观察到安全问题。环孢素似乎对新发HAM/TSP或出现复发的慢性HAM/TSP有效。然而，这种类固醇节省疗法的持续时间和安全性尚不清楚，应进一步研究。