Tian Hong-Chang, Liu Jing-Quan, Kang Xiao-Yang, Wei Dai-Xu, Zhang Chuan, Du Jing-Cheng, Yang Bin, Chen Xiang, Yang Chun-Sheng
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:1571-4. doi: 10.1109/EMBC.2014.6943903.
Owing to interacting with the living tissue directly, the electrode-tissue interface largely determines the performance of the whole bioelectronics devices. The miniaturization of biomedical electronic components requires interface materials to possess properties including excellent electrical performance, good biocompatibility and compatibility with microelectronic fabrication process. Considering the unique characteristics and wide applications in biomedical domain of conducting polymer and graphene, composite film consists of poly(3,4-ethylenedioxythiophene) (PEDOT) and graphene oxide (GO) is proposed as electrode-tissue interface in this work. The facilely electrochemically synthesized PEDOT/GO coating on microelectrodes shows low impedance, high charge storage capacity and good biocompatibility to act as electrode-tissue interface. As a result, the composite film is a potential biomaterial as electrode-tissue interface for tissue engineering and further implantable electrophysiological devices.
由于直接与活组织相互作用，电极 - 组织界面在很大程度上决定了整个生物电子器件的性能。生物医学电子元件的小型化要求界面材料具备优异的电学性能、良好的生物相容性以及与微电子制造工艺的兼容性等特性。考虑到导电聚合物和石墨烯在生物医学领域的独特特性及广泛应用，本文提出了一种由聚（3,4 - 乙撑二氧噻吩）（PEDOT）和氧化石墨烯（GO）组成的复合膜作为电极 - 组织界面。在微电极上通过简便的电化学合成方法制备的PEDOT/GO涂层表现出低阻抗、高电荷存储容量以及良好的生物相容性，可作为电极 - 组织界面。因此，该复合膜是一种有潜力的生物材料，可作为组织工程及进一步的可植入电生理设备的电极 - 组织界面。
