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体内对哺乳动物外周神经的磁刺激:功能性电刺激的替代方法

Magnetic stimulation of mammalian peripheral nerves in vivo: an alternative to functional electrical stimulation.

作者信息

Kagan Zachary B, RamRakhyani Anil Kumar, Khan Faisal, Lazzi Gianluca, Normann Richard A, Warren David J

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:2573-6. doi: 10.1109/EMBC.2014.6944148.

DOI:10.1109/EMBC.2014.6944148
PMID:25570516
Abstract

Functional electrical stimulation is the current gold standard for stimulating neuronal interfaces for functional neuromuscular and cortical applications, but it is not without its drawbacks. One such fault is the need to have direct electrical contact with the nerve tissue, and any side effects this causes. Functional magnetic stimulation, which works though electromagnetic induction, does not require electrical contact and may be a viable alternative to functional electrical stimulation. We are investigating the capabilities of magnetic stimulation with centimeter scale (< 2.5 cm) coils in feline and rodent sciatic nerves in vivo. We have shown that magnetic stimulation can consistently produce the same levels of neuromuscular activation as electrical stimulation. Additionally, the position of the coil relative to the nerve influences neuromuscular activation, suggesting the possibility of selective muscle activation.

摘要

功能性电刺激是用于功能性神经肌肉和皮层应用中刺激神经元接口的当前金标准,但它并非没有缺点。其中一个缺点是需要与神经组织进行直接电接触以及由此产生的任何副作用。通过电磁感应起作用的功能性磁刺激不需要电接触,可能是功能性电刺激的一个可行替代方案。我们正在研究在猫和啮齿动物体内使用厘米级(<2.5厘米)线圈进行磁刺激的能力。我们已经表明,磁刺激能够始终如一地产生与电刺激相同水平的神经肌肉激活。此外,线圈相对于神经的位置会影响神经肌肉激活,这表明存在选择性肌肉激活的可能性。

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Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study.使用毫米级磁线圈阵列对大鼠坐骨神经进行选择性刺激:一项模拟研究。
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