Varon Carolina, Caicedo Alexander, Jansen Katrien, Lagae Lieven, Van Huffel Sabine
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:3789-90. doi: 10.1109/EMBC.2014.6944448.
Epileptic seizures have a clear effect on the regulatory mechanisms of the autonomic nervous system, especially on the cardiac and respiratory controls. Changes in heart rate and respiration are well known to occur around the onset of the seizure. This paper studies the ECG signals recorded from patients suffering from epilepsy, whose ages ranged from 3 to 48 years. Both focal and generalized seizures are considered. Changes in cardiorespiratory control and coupling, are assessed using phase rectified signal averaging (PRSA), which is a technique that finds quasi-periodicities in noisy and non-stationary signals. A positive predictive value (PPV) of 86.21% with sensitivity of 100% was obtained for focal seizures, and a PPV of 84.3% with 93.1% sensitivity for generalized seizures.
癫痫发作对自主神经系统的调节机制有明显影响，尤其是对心脏和呼吸控制方面。众所周知，在癫痫发作开始时会出现心率和呼吸的变化。本文研究了年龄在3至48岁之间的癫痫患者记录的心电图信号。研究考虑了局灶性发作和全身性发作。使用相位整流信号平均法（PRSA）评估心肺控制和耦合的变化，PRSA是一种在噪声和非平稳信号中寻找准周期性的技术。局灶性发作的阳性预测值（PPV）为86.21%，敏感性为100%；全身性发作的PPV为84.3%，敏感性为93.1%。
