白细胞介素1A 3'-非翻译区插入/缺失多态性与前列腺癌易感性相关

[Insertion/deletion polymorphism of IL1A 3'-UTR associated with the susceptibility of prostate cancer ].

作者信息

Liao Hong, Zhang Lin, Cheng Peng, Pu Yan, Wu Yi, Li Zeng, Xiao Ying-ming, Yang Sheng-ke'

机构信息

Department of Urology, Sichaun Cancer Hospital, Chengdu, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Nov;45(6):956-9.

PMID:25571723

Abstract

OBJECTIVE

To identify the association between the insertion/deletion polymorphism of interleukin- 1A gene (IL1A) and the susceptibility of prostate cancer (PCA).

METHODS

We performed a case-control study enrolling 131 PCA patients and 229 healthy control subjects in a Chinese Han population. The TTCA insertion/ deletion polymorphism (rs3783553) in 3'-UTR of IL1A gene was genotyped by PCR-RFLP method.

RESULTS

The genotype distribution of rs3783553 in both groups met the requirements of Hardy-Weinberg equilibrium. Significantly reduced PCA risk was associated with D/I and I/I genotype compared to D/D genotype (P<0. 001, OR=O. 48, 95%CI: 0.31-0.74), and allele I is associated with the reduced PCA risk (P=0. 001,OR=0. 56,95% CI: 0. 40-0. 79).

CONCLUSION

TTCA insertion allele of rs3783553 contributes to the reduction of the susceptibility to prostate cancer.

摘要

目的

确定白细胞介素-1A基因（IL1A）插入/缺失多态性与前列腺癌（PCA）易感性之间的关联。

方法

我们开展了一项病例对照研究，纳入了中国汉族人群中的131例PCA患者和229名健康对照者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对IL1A基因3'-非翻译区（UTR）的TTCA插入/缺失多态性（rs3783553）进行基因分型。

结果

两组中rs3783553的基因型分布均符合哈迪-温伯格平衡的要求。与D/D基因型相比，D/I和I/I基因型与PCA风险显著降低相关（P<0.001，比值比[OR]=0.48，95%置信区间[CI]：0.31-0.74），且等位基因I与PCA风险降低相关（P=0.001，OR=0.56，95%CI：0.40-0.79）。