抑郁发作中的瘦素：单相抑郁和双相抑郁之间有差异吗？
Leptin in depressive episodes: is there a difference between unipolar and bipolar depression?
作者信息
Cordas Gisele, Gazal Marta, Schuch Eduardo M, Spessato Bárbara C, Branco Jerônimo, Jansen Karen, Oses Jean P, Quevedo Luciana A, Souza Luciano D M, Pinheiro Ricardo T, Portela Luiz Valmor, da Silva Ricardo A, Lara Diogo R, Kaster Manuella P, Ghisleni Gabriele
机构信息
Programa de Pós-Graduação em Saúde e Comportamento, Centro de Ciências da Vida e da Saúde, Universidade Católica de Pelotas, Pelotas, Brazil.
出版信息
Neuroendocrinology. 2015;101(1):82-6. doi: 10.1159/000371803. Epub 2015 Jan 5.
OBJECTIVE
The present study investigated whether peripheral leptin levels are associated with current depressive episodes in a cross-sectional study nested within a population-based study.
METHODS
The Mini-International Neuropsychiatric Interview (MINI) 5.0 was used to assess the presence of current depressive episodes. The sample was composed of 206 subjects (103 controls and 103 subjects with a current depressive episode) paired by gender, BMI and age. Medication use and lifestyle characteristics were self-reported.
RESULTS
Serum leptin levels were lower in currently depressive subjects (10.9 ± 12.0 ng/ml) than in the control group (20.3 ± 24.0 ng/ml; p = 0.023). According to the clinical diagnosis, individuals with bipolar depression present lower leptin levels (8.4 ± 8.1 ng/ml) than those with unipolar depression (12.0 ± 13.4 ng/ml) and the control group (20.3 ± 24.0 ng/ml; p = 0.031). In addition, ANCOVA showed that leptin is an independent factor associated with current depressive episodes (p = 0.018).
CONCLUSION
A decreased leptin level might be a useful peripheral marker associated with depressive episodes in the context of bipolar disorder.
目的
在一项基于人群的研究中的横断面研究中，本研究调查了外周瘦素水平是否与当前的抑郁发作相关。
方法
使用迷你国际神经精神访谈（MINI）5.0评估当前抑郁发作的存在情况。样本由按性别、体重指数和年龄配对的206名受试者（103名对照和103名有当前抑郁发作的受试者）组成。药物使用和生活方式特征通过自我报告获得。
结果
当前抑郁的受试者血清瘦素水平（10.9±12.0纳克/毫升）低于对照组（20.3±24.0纳克/毫升；p = 0.023）。根据临床诊断，双相抑郁症患者的瘦素水平（8.4±8.1纳克/毫升）低于单相抑郁症患者（12.0±13.4纳克/毫升）和对照组（20.3±24.0纳克/毫升；p = 0.031）。此外，协方差分析表明瘦素是与当前抑郁发作相关的独立因素（p = 0.018）。
结论
瘦素水平降低可能是双相情感障碍背景下与抑郁发作相关的有用外周标志物。
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