Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, 130041, Changchun, Jilin, China.
Cell Death Dis. 2018 Oct 26;9(11):1096. doi: 10.1038/s41419-018-1129-1.
Leptin, produced and secreted by white adipose tissue, plays a critical role in regulating body weight, food intake, and energy metabolism. Recently, several studies have identified an underlying role for leptin in regulation of mood and cognition via regulation of synaptic changes in the brain that have been associated with antidepressant-like actions. Brain neural plasticity occurs in response to a range of intrinsic and extrinsic stimuli, including those that may mediate the effects of antidepressants. Neural plasticity theories of depression are thought to explain multiple aspects of depression and the effects of antidepressants. It is also well documented that leptin has effects on neural plasticity. This review summarizes the recent literature on the role of leptin in neural plasticity in order to elaborate the possible mechanism of leptin's antidepressant-like effects. Recent findings provide new insights into the underlying mechanisms of neural plasticity in depression. Leptin may influence these mechanisms and consequently constitute a possible target for novel therapeutic approaches to the treatment of depression.
瘦素由白色脂肪组织产生和分泌，在调节体重、食物摄入和能量代谢方面发挥着关键作用。最近，几项研究确定了瘦素在调节情绪和认知方面的潜在作用，其通过调节与抗抑郁作用相关的大脑中的突触变化来实现。大脑神经可塑性是对一系列内在和外在刺激的反应，包括可能介导抗抑郁药作用的刺激。抑郁症的神经可塑性理论被认为可以解释抑郁症的多个方面和抗抑郁药的作用。有充分的文献记载表明瘦素对神经可塑性有影响。这篇综述总结了瘦素在神经可塑性中的作用的最新文献，以阐述瘦素产生抗抑郁样作用的可能机制。最近的发现为抑郁症中神经可塑性的潜在机制提供了新的见解。瘦素可能影响这些机制，因此可能成为治疗抑郁症的新治疗方法的潜在靶点。
