从RNA世界到RNA/蛋白质世界：某些核糖开关结合物种的贡献？

From the RNA world to the RNA/protein world: contribution of some riboswitch-binding species?

作者信息

da Silva José A L

机构信息

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal.

出版信息

J Theor Biol. 2015 Apr 7;370:197-201. doi: 10.1016/j.jtbi.2014.12.013. Epub 2015 Jan 5.

DOI:10.1016/j.jtbi.2014.12.013

PMID:25571850

Abstract

Some amino acids and their formal derivatives, currently riboswitch-binding species, could have interacted with polyribonucletides in prebiotic environments, leading to the peptide formation. If the resulting compounds had led to a sustainable polymerization of amino acids and the new structures had catalytic activity, such would have been an important contribution to the transition from the RNA world to the RNA/Protein world.

摘要

一些氨基酸及其形式衍生物，目前是核糖开关结合物种，可能在益生元环境中与多核糖核苷酸相互作用，从而导致肽的形成。如果所产生的化合物导致了氨基酸的可持续聚合，并且新结构具有催化活性，那么这将是从RNA世界向RNA/蛋白质世界转变的重要贡献。