从山黧豆根皮中分离得到的二氢丹参酮/紫草素低聚物的伤口愈合活性。

Wound-healing activity of an oligomer of alkannin/shikonin, isolated from root bark of Onosma echioides.

机构信息

a Saraswathi Vidya Bhavan's College of Pharmacy , Kalyan Shil Road, Sankaranagar, Sonarpada, Dombivli (E) 421203 Thane, Maharashtra , India.

出版信息

Nat Prod Res. 2015;29(16):1584-8. doi: 10.1080/14786419.2014.986126. Epub 2015 Jan 9.

DOI:10.1080/14786419.2014.986126

PMID:25572039

Abstract

Root bark of Onosma echioides belonging to the family Boraginaceae is reported to be rich in naphthaquinones such as alkannins and shikonins. In this study, a dimer of alkannin/shikonin was isolated from the petroleum ether (60-80 C) extract of the bark, and the structure of the same was elucidated through spectral studies (UV, IR, NMR, MS and DEPT). The petroleum ether extract was found to contain 62.4% (w/w) of the dimer of alkannin/shikonin, and the compound is found to promote wound-healing process, when studied in the excision and incision wound models in albino rats.

摘要

报春花科琉璃草属植物琉璃草根皮富含萘醌类化合物，如alkanins 和 shikonins。本研究从树皮的石油醚（60-80°C）提取物中分离出 alkanin/shikonin 的二聚体，并通过光谱研究（UV、IR、NMR、MS 和 DEPT）阐明了其结构。石油醚提取物中含有 62.4%（w/w）的 alkanin/shikonin 二聚体，在白化大鼠的切除和切口伤口模型中研究发现，该化合物可促进伤口愈合过程。