天然化合物促进伤口愈合的综合评价：以生物活性为靶点
A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.
机构信息
Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
Department of Medical Device Development, College of Medicine, Seoul National University, Seoul 03080, Korea.
出版信息
Int J Mol Sci. 2022 Aug 24;23(17):9573. doi: 10.3390/ijms23179573.
Wound healing is a recovering process of damaged tissues by replacing dysfunctional injured cellular structures. Natural compounds for wound treatment have been widely used for centuries. Numerous published works provided reviews of natural compounds for wound healing applications, which separated the approaches based on different categories such as characteristics, bioactivities, and modes of action. However, current studies provide reviews of natural compounds that originated from only plants or animals. In this work, we provide a comprehensive review of natural compounds sourced from both plants and animals that target the different bioactivities of healing to promote wound resolution. The compounds were classified into four main groups (i.e., anti-inflammation, anti-oxidant, anti-bacterial, and collagen promotion), mostly studied in current literature from 1992 to 2022. Those compounds are listed in tables for readers to search for their origin, bioactivity, and targeting phases in wound healing. We also reviewed the trend in using natural compounds for wound healing.
伤口愈合是通过替换功能失调的受损细胞结构来恢复受损组织的过程。天然化合物在伤口治疗中已经被广泛应用了几个世纪。大量已发表的文献综述了天然化合物在伤口愈合应用中的作用，这些文献综述根据不同的分类方法（如特性、生物活性和作用模式）对方法进行了区分。然而，目前的研究提供了仅来源于植物或动物的天然化合物的综述。在这项工作中，我们综述了天然化合物的来源，这些化合物既来自植物也来自动物，针对愈合的不同生物活性来促进伤口愈合。这些化合物被分为四大类（即抗炎、抗氧化、抗菌和促进胶原形成），在 1992 年至 2022 年的文献中主要对其进行了研究。这些化合物被列在表格中，供读者查找其来源、生物活性和在伤口愈合中的靶向阶段。我们还回顾了使用天然化合物进行伤口愈合的趋势。
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