Ivleva A Ia, Udotova S A, Lepakhin V K, Tomashevskiĭ I O
Farmakol Toksikol. 1989 Sep-Oct;52(5):73-6.
Nifedipine is an effective agent in hypertensive emergencies as well as in the long-term management of hypertension especially for the patients with an increased risk of cerebral hypoperfusion. Nifedipine exerts its blood lowering effect by reducing total peripheral resistance including cerebrovascular resistance. Despite the marked reduction of perfusion pressure, the cerebral blood flow is maintained by nifedipine.
硝苯地平在高血压急症以及高血压的长期管理中是一种有效药物,尤其适用于有脑灌注不足风险增加的患者。硝苯地平通过降低包括脑血管阻力在内的总外周阻力来发挥其降压作用。尽管灌注压显著降低,但硝苯地平仍能维持脑血流量。