West German Cancer Center, Department of Dermatology, University Hospital Essen, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
West German Cancer Center, Department of Dermatology, University Hospital Essen, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
J Invest Dermatol. 2015 Feb;135(2):335-336. doi: 10.1038/jid.2014.420.
Sequencing samples of melanoma for targetable mutations has become a standard of care for metastatic disease. In this issue, Siroy et al. demonstrate how clinical genetic analysis is moving from a single-gene Sanger-sequencing approach to targeted next-generation sequencing. They present data on a large cohort of patients with advanced melanoma, and their data support previous findings and also present novel aspects of melanoma genetics.
对黑色素瘤进行靶向突变的测序已成为转移性疾病的标准治疗方法。在本期中，Siroy 等人展示了临床基因分析如何从单基因 Sanger 测序方法转向靶向下一代测序。他们提供了大量晚期黑色素瘤患者的数据，这些数据支持了先前的发现，并呈现了黑色素瘤遗传学的新方面。
