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Localization of DNA repair synthesis by human cell extracts to a short region at the site of a lesion.

作者信息

Hansson J, Munn M, Rupp W D, Kahn R, Wood R D

机构信息

Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, United Kingdom.

出版信息

J Biol Chem. 1989 Dec 25;264(36):21788-92.

PMID:2557339
Abstract

Double-stranded bacteriophage M13 DNA molecules were constructed containing a single specifically placed 2-(acetylamino)fluorene adduct or a single 4'-hydroxymethyl-4,5',8-trimethylpsoralen monoadduct. These circular DNA molecules were used to analyze in vitro DNA repair synthesis by cell extracts from normal human lymphoid cell lines. Both types of lesions stimulate DNA repair synthesis at the site of the adduct. DNA repair synthesis induced by the 2-(acetyl-amino)fluorene adduct took place in the damaged strand and was confined to a region within a 31-base pair restriction fragment around the adduct.

摘要

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