从核苷酸切除修复的靶位点起始染色质组装并双向传播。
Initiation and bidirectional propagation of chromatin assembly from a target site for nucleotide excision repair.
作者信息
Gaillard Pierre-Henri L, Moggs J G, Roche D M, Quivy J P, Becker P B, Wood R D, Almouzni G
机构信息
Institut Curie/Research section UMR 144 du CNRS, 26 rue d'Ulm 75231 Paris cedex 05, France.
出版信息
EMBO J. 1997 Oct 15;16(20):6281-9. doi: 10.1093/emboj/16.20.6281.
Abstract
To restore full genomic integrity in a eukaryotic cell, DNA repair processes have to be coordinated with the resetting of nucleosomal organization. We have established a cell-free system using Drosophila embryo extracts to investigate the mechanism linking de novo nucleosome formation to nucleotide excision repair (NER). Closed-circular DNA containing a uniquely placed cisplatin-DNA adduct was used to follow chromatin assembly specifically from a site of NER. Nucleosome formation was initiated from a target site for NER. The assembly of nucleosomes propagated bidirectionally, creating a regular nucleosomal array extending beyond the initiation site. Furthermore, this chromatin assembly was still effective when the repair synthesis step in the NER process was inhibited.
摘要
为了在真核细胞中恢复完整的基因组完整性，DNA修复过程必须与核小体组织的重置相协调。我们建立了一个无细胞系统，利用果蝇胚胎提取物来研究将从头核小体形成与核苷酸切除修复（NER）联系起来的机制。含有独特放置的顺铂-DNA加合物的闭环DNA被用来专门追踪从NER位点开始的染色质组装。核小体形成从NER的靶位点开始。核小体的组装双向传播，形成一个延伸到起始位点之外的规则核小体阵列。此外，当NER过程中的修复合成步骤受到抑制时，这种染色质组装仍然有效。
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