Borger J A, Barbosa J L, Lehan C A
J Fla Med Assoc. 1989 Dec;76(12):1023-6.
Four patients presented with large intra-abdominal masses. Three patients were diagnosed as having hepatoblastomas of the right hepatic lobe, one of the left lobe. Initially these tumors were unresectable, and after biopsy each patient was treated with a standardized chemotherapy protocol. All tumors decreased remarkably in size and were resected successfully. Postoperative chemotherapy was then instituted and, as of this date, three of the children appear to be disease free; the fourth had a pulmonary metastatic lesion completely resected. Contrary to the dismal past history of patients with initially unresectable hepatoblastomas, treatment with preoperative chemotherapy, surgery and postoperative chemotherapy has had most rewarding results.
4例患者出现腹腔内巨大肿块。3例被诊断为右肝叶肝母细胞瘤，1例为左肝叶肝母细胞瘤。起初这些肿瘤无法切除，活检后每位患者均接受标准化化疗方案治疗。所有肿瘤体积均显著缩小并成功切除。随后进行术后化疗，截至目前，3名儿童似乎无疾病；第4名儿童的肺转移病灶被完全切除。与最初无法切除的肝母细胞瘤患者过去的悲惨病史相反，术前化疗、手术及术后化疗的治疗取得了非常好的效果。
