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阿奇霉素对导尿管相关尿路感染分离株的作用。

Effects of azithromycin on isolates from catheter-associated urinary tract infection.

作者信息

Xu Zhi-Gang, Gao Yu, He Jian-Guo, Xu Wei-Feng, Jiang Mei, Jin Huan-Sheng

机构信息

Urologic Institute of Chongqing Red Cross Hospital, Chongqing 400020, P.R. China.

Urologic Institute of Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China.

出版信息

Exp Ther Med. 2015 Feb;9(2):569-572. doi: 10.3892/etm.2014.2120. Epub 2014 Dec 8.

DOI:10.3892/etm.2014.2120
PMID:25574236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4280936/
Abstract

is a common pathogenic bacterium in urinary tract infections (UTIs), particularly catheter-associated UTIs. The aim of this study was to investigate the effect of azithromycin (AZM) on isolated from UTIs. Isolates were identified by biochemical assays and the Vitek system. Antimicrobial susceptibility was determined using the disk diffusion assay. Biofilm formation and adhesion were assayed using a crystal violet staining method. The swimming motility was assayed on agar plates. The elastase activity and rhamnolipid production were determined by the elastin-Congo red method and orcinol reaction, respectively. A total of 32 bacterial isolates were collected from 159 urinary catheters and eight of them were isolates. The results showed that the isolates had stronger biofilm formation capability and the biofilms were thicker than those of PAO1. AZM inhibited biofilm formation and adhesion on urinary catheters, and also decreased swimming motility and the production of virulence factors. The results of this study indicated that AZM is potentially a good choice for use in the treatment of UTIs.

摘要

是尿路感染（UTIs），尤其是导管相关尿路感染中的常见致病细菌。本研究的目的是调查阿奇霉素（AZM）对从尿路感染中分离出的[细菌名称未给出]的影响。通过生化测定和Vitek系统鉴定分离株。使用纸片扩散法测定抗菌药敏性。使用结晶紫染色法测定生物膜形成和黏附。在琼脂平板上测定游动性。分别通过弹性蛋白-刚果红法和间苯二酚反应测定弹性蛋白酶活性和鼠李糖脂产量。从159根导尿管中总共收集到32株细菌分离株，其中8株是[细菌名称未给出]分离株。结果表明，[细菌名称未给出]分离株具有更强的生物膜形成能力，且其生物膜比PAO1的生物膜更厚。AZM抑制导尿管上的生物膜形成和黏附，还降低游动性和毒力因子的产生。本研究结果表明，AZM可能是治疗尿路感染的良好选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70b5/4280936/8bdb06666351/ETM-09-02-0569-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70b5/4280936/22e1807e6af4/ETM-09-02-0569-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70b5/4280936/732c2cc9ae6a/ETM-09-02-0569-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70b5/4280936/8bdb06666351/ETM-09-02-0569-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70b5/4280936/22e1807e6af4/ETM-09-02-0569-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70b5/4280936/732c2cc9ae6a/ETM-09-02-0569-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70b5/4280936/8bdb06666351/ETM-09-02-0569-g02.jpg

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PLoS One. 2013 Aug 13;8(8):e71845. doi: 10.1371/journal.pone.0071845. eCollection 2013.
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