利用光学相干断层扫描对小鼠模型主动脉瓣动力学进行体外4D可视化。
Ex vivo 4D visualization of aortic valve dynamics in a murine model with optical coherence tomography.
作者信息
Schnabel Christian, Jannasch Anett, Faak Saskia, Waldow Thomas, Koch Edmund
机构信息
Technische Universität Dresden, Faculty of Medicine CGC, Department of Anesthesiology and Intensive Care Medicine and Clinical Sensoring and Monitoring, Germany ; Authors contributed equally to this paper.
Technische Universität Dresden, Faculty of Medicine CGC, Clinic for Cardiac Surgery, Germany ; Authors contributed equally to this paper.
出版信息
Biomed Opt Express. 2014 Nov 7;5(12):4201-12. doi: 10.1364/BOE.5.004201. eCollection 2014 Dec 1.
The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain and undergo fatigue, which impinge upon cardiac output. The knowledge about changes of the dynamic behavior and the possibility of early stage diagnosis could lead to the development of new treatment strategies. Animal models are suited for the development and evaluation of new experimental approaches and therefor innovative imaging techniques are necessary. In this study, we present the time resolved visualization of healthy and calcified aortic valves in an ex vivo artificially stimulated heart model with 4D optical coherence tomography and high-speed video microscopy.
心脏及其机械部件，尤其是心脏瓣膜和瓣叶，承受着巨大的压力并会发生疲劳，这会影响心输出量。关于动态行为变化以及早期诊断可能性的知识可能会促成新治疗策略的发展。动物模型适用于新实验方法的开发和评估，因此创新的成像技术是必要的。在本研究中，我们通过四维光学相干断层扫描和高速视频显微镜，展示了在体外人工刺激心脏模型中健康和钙化主动脉瓣的时间分辨可视化。
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