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Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.钙化性主动脉瓣疾病：并非简单的退行性过程：美国国立心肺血液研究所主动脉狭窄工作组的综述及研究议程。执行摘要：钙化性主动脉瓣疾病——2011年更新版
Circulation. 2011 Oct 18;124(16):1783-91. doi: 10.1161/CIRCULATIONAHA.110.006767.
2
Lipoprotein(a) and calcific aortic valve stenosis: A systematic review.脂蛋白(a)与钙化性主动脉瓣狭窄：系统综述。
Prog Cardiovasc Dis. 2020 Jul-Aug;63(4):496-502. doi: 10.1016/j.pcad.2020.06.002. Epub 2020 Jun 8.
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Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.钙化性主动脉瓣疾病：钙化性主动脉瓣疾病研究联盟的共识总结
Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2387-93. doi: 10.1161/ATVBAHA.114.302523. Epub 2014 Sep 4.
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Demographic characteristics of patients undergoing aortic valve replacement for stenosis: relation to valve morphology.因狭窄接受主动脉瓣置换术患者的人口统计学特征：与瓣膜形态的关系。
Heart. 1996 Feb;75(2):174-8. doi: 10.1136/hrt.75.2.174.
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Osseous and chondromatous metaplasia in calcific aortic valve stenosis.钙化性主动脉瓣狭窄中的骨化生和软骨化生
Cardiovasc Pathol. 2016 Jan-Feb;25(1):18-24. doi: 10.1016/j.carpath.2015.08.008. Epub 2015 Aug 29.
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Calcific Aortic Stenosis - Inflammatory Disease.钙化性主动脉瓣狭窄 - 炎症性疾病。
Cesk Patol. 2024;60(2):124-128.
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[Differences between degenerative (non-inflammatory) calcinosis- related stenosis of the aortic valve and the rheumatic calcinosis- induced aortic valve stenosis].[退行性（非炎性）钙化相关主动脉瓣狭窄与风湿性钙化所致主动脉瓣狭窄之间的差异]
Kardiologiia. 1991 Jan;31(1):56-9.
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The 'valvulo-metabolic' risk in calcific aortic valve disease.钙化性主动脉瓣疾病中的“瓣膜-代谢”风险
Can J Cardiol. 2007 Oct;23 Suppl B(Suppl B):32B-39B. doi: 10.1016/s0828-282x(07)71008-5.
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Hypercholesterolemia association with aortic stenosis of various etiologies.高胆固醇血症与各种病因的主动脉瓣狭窄的关联。
J Card Surg. 2009 Mar-Apr;24(2):146-50. doi: 10.1111/j.1540-8191.2009.00814.x.
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Cronic non-rheumatic valvular heart disease. An autopsy study.慢性非风湿性瓣膜性心脏病。一项尸检研究。
Acta Pathol Microbiol Scand A. 1976 May;84(3):247-52.

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Fuelling aortic stenosis: the integral role of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-mediated glycolysis in Lp(a)-induced valve inflammation.助力主动脉瓣狭窄：6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3介导的糖酵解在脂蛋白(a)诱导的瓣膜炎症中的重要作用
Eur Heart J Open. 2025 Jun 6;5(4):oeaf068. doi: 10.1093/ehjopen/oeaf068. eCollection 2025 Jul.
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Unraveling the Link Between Aortic Stenosis and Atherosclerosis: What Have We Learned?解析主动脉瓣狭窄与动脉粥样硬化之间的联系：我们学到了什么？
Medicina (Kaunas). 2025 Jul 30;61(8):1375. doi: 10.3390/medicina61081375.
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Extracellular Matrix Dynamics in Aortic Valve Health and Disease: Insights into Fibrocalcific Remodeling and Creation of Biomimetic Platforms.主动脉瓣健康与疾病中的细胞外基质动力学：对纤维钙化重塑及仿生平台构建的见解
J Heart Valve Soc. 2024 Oct-Dec;1(1). doi: 10.1177/30494826241296675. Epub 2024 Dec 26.
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Diabetes and calcific aortic valve disease: controversy of clinical outcomes in diabetes after aortic valve replacement.糖尿病与钙化性主动脉瓣疾病：主动脉瓣置换术后糖尿病患者临床结局的争议
Front Endocrinol (Lausanne). 2025 Jul 30;16:1577762. doi: 10.3389/fendo.2025.1577762. eCollection 2025.
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Significance of APOB/APOA1 Ratio in the Prediction of Calcific Aortic Valve Disease.载脂蛋白B/载脂蛋白A1比值在钙化性主动脉瓣疾病预测中的意义
Cardiovasc Ther. 2025 Aug 3;2025:5528174. doi: 10.1155/cdr/5528174. eCollection 2025.
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Nutrient restriction protects against valve interstitial cell calcification by upregulating ubiquitin mediated proteolysis.营养限制通过上调泛素介导的蛋白水解作用来预防瓣膜间质细胞钙化。
Front Cardiovasc Med. 2025 Jul 21;12:1586775. doi: 10.3389/fcvm.2025.1586775. eCollection 2025.
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Amyloid-induced mineralization: From biological systems to biomimetic materials.淀粉样蛋白诱导的矿化：从生物系统到仿生材料。
Bioact Mater. 2025 May 21;51:469-493. doi: 10.1016/j.bioactmat.2025.04.036. eCollection 2025 Sep.
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Diabetes and calcific aortic valve disease: implications of glucose-lowering medication as potential therapy.糖尿病与钙化性主动脉瓣疾病：降糖药物作为潜在治疗方法的意义
Front Pharmacol. 2025 Apr 28;16:1583267. doi: 10.3389/fphar.2025.1583267. eCollection 2025.
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Association between blood pressure traits, hypertension, antihypertensive drugs and calcific aortic valve stenosis: a mendelian randomization study.血压特征、高血压、抗高血压药物与钙化性主动脉瓣狭窄之间的关联：一项孟德尔随机化研究
J Geriatr Cardiol. 2025 Mar 28;22(3):351-360. doi: 10.26599/1671-5411.2025.03.008.
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Inflammation via JAK-STAT/HIF-1α Drives Metabolic Changes in Pentose Phosphate Pathway and Glycolysis That Support Aortic Valve Cell Calcification.通过JAK-STAT/HIF-1α介导的炎症驱动磷酸戊糖途径和糖酵解中的代谢变化，这些变化支持主动脉瓣细胞钙化。
Arterioscler Thromb Vasc Biol. 2025 Jul;45(7):e232-e249. doi: 10.1161/ATVBAHA.124.322375. Epub 2025 May 1.

本文引用的文献

1
Bicuspid aortic valve disease: the role of oxidative stress in Lrp5 bone formation.二叶式主动脉瓣疾病：氧化应激在 Lrp5 骨形成中的作用。
Cardiovasc Pathol. 2011 May-Jun;20(3):168-76. doi: 10.1016/j.carpath.2010.11.007. Epub 2011 Jan 22.
2
Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease.在晚期主动脉瓣疾病中，存在对成骨信号的主动调节的证据。
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2482-6. doi: 10.1161/ATVBAHA.110.211029. Epub 2010 Sep 23.
3
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.动脉和主动脉瓣钙化与骨质疏松性骨重塑呈负相关：炎症的作用。
Eur Heart J. 2010 Aug;31(16):1975-84. doi: 10.1093/eurheartj/ehq237. Epub 2010 Jul 2.
4
Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial.瑞舒伐他汀降脂治疗对主动脉瓣狭窄进展的影响：主动脉瓣狭窄进展观察研究的结果：评价瑞舒伐他汀的效果（ASTROMER）试验。
Circulation. 2010 Jan 19;121(2):306-14. doi: 10.1161/CIRCULATIONAHA.109.900027. Epub 2010 Jan 4.
5
Mechanisms of aortic valve calcification: the LDL-density-radius theory: a translation from cell signaling to physiology.主动脉瓣钙化的机制：LDL-密度-半径理论：从细胞信号转导到生理学的转化。
Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H5-15. doi: 10.1152/ajpheart.00824.2009. Epub 2009 Oct 23.
6
Lowering plasma cholesterol levels halts progression of aortic valve disease in mice.降低血浆胆固醇水平可阻止小鼠主动脉瓣疾病的进展。
Circulation. 2009 May 26;119(20):2693-701. doi: 10.1161/CIRCULATIONAHA.108.834614. Epub 2009 May 11.
7
Role of the MAPK/ERK pathway in valvular interstitial cell calcification.丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）信号通路在瓣膜间质细胞钙化中的作用
Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1748-57. doi: 10.1152/ajpheart.00099.2009. Epub 2009 Apr 10.
8
Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix.瓣膜间质细胞的钙化受细胞外基质硬度的调节。
Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):936-42. doi: 10.1161/ATVBAHA.108.182394. Epub 2009 Mar 19.
9
Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential.具有强大成骨钙化潜能的主动脉瓣间充质祖细胞的鉴定与表征
Am J Pathol. 2009 Mar;174(3):1109-19. doi: 10.2353/ajpath.2009.080750. Epub 2009 Feb 13.
10
Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease.升高的周期性牵张改变主动脉瓣叶的基质重塑：对退行性主动脉瓣疾病的影响。
Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H756-64. doi: 10.1152/ajpheart.00900.2008. Epub 2009 Jan 16.

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.

作者信息

Rajamannan Nalini M, Evans Frank J, Aikawa Elena, Grande-Allen K Jane, Demer Linda L, Heistad Donald D, Simmons Craig A, Masters Kristyn S, Mathieu Patrick, O'Brien Kevin D, Schoen Frederick J, Towler Dwight A, Yoganathan Ajit P, Otto Catherine M

机构信息

Division of Cardiology and Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

出版信息

Circulation. 2011 Oct 18;124(16):1783-91. doi: 10.1161/CIRCULATIONAHA.110.006767.

DOI:10.1161/CIRCULATIONAHA.110.006767
PMID:22007101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3306614/
Abstract
摘要