Mallick D, Saha M, Chakrabarti S, Chakrabarty J
Department of Pathology, ESI PGIMSR, Manicktala Kolkata, Kolkata, West Bengal, India.
J Nepal Health Res Counc. 2014 May-Aug;12(27):144-6.
Tuberculosis affects many organs, however isolated tubercular breast lesion is rare. Clinically as well as radiologically it may mimic both pyogenic abscess and malignancy. One such case is being reported where a middle aged woman presented with painful, gradually increasing breast lump and was diagnosed clinically, radiologically, cytologically and even histologically as pyogenic abscess. Poor response to antibiotics raised the suspicion of malignancy for which repeat fine needle aspiration cytology was done. Well formed granulomas, necrosis and finally demonstration of acid fast bacilli established the diagnosis of tubercular abscess. No other organs were involved by tuberculosis in this case. Patient responded well to antitubercular drugs. Thus diagnostic challenge lies in the demonstration of acid fast bacilli in cases of equivocal morphology in routine cytology as well as histology. High clinical suspicion, poor response to antibiotics, suggestive radiological findings, cytology, histology and demonstration of acid fast bacilli -all contributes to the diagnosis of breast tuberculosis.
肺结核可累及多个器官,但孤立性乳腺结核病变较为罕见。在临床和影像学上,它可能同时酷似化脓性脓肿和恶性肿瘤。本文报告了这样一例病例,一名中年女性出现疼痛且逐渐增大的乳腺肿块,临床、放射学、细胞学甚至组织学检查均诊断为化脓性脓肿。对抗生素治疗反应不佳引发了对恶性肿瘤的怀疑,为此再次进行了细针穿刺细胞学检查。形成良好的肉芽肿、坏死以及最终抗酸杆菌的发现确立了结核性脓肿的诊断。该病例中无其他器官受到结核累及。患者对抗结核药物反应良好。因此,诊断的挑战在于在常规细胞学和组织学形态不明确的病例中发现抗酸杆菌。高度的临床怀疑、对抗生素治疗反应不佳、提示性的放射学表现、细胞学、组织学以及抗酸杆菌的发现——所有这些都有助于乳腺结核的诊断。