Pearson E C
Department of Haematological Medicine, University Clinical School, Cambridge, UK.
Med Hypotheses. 1989 Nov;30(3):175-7. doi: 10.1016/0306-9877(89)90058-3.
Auer rods are cytoplasmic inclusions found only in the leukaemic cells of some cases of acute myeloid leukaemia (AML). The ultrastructure of Auer rods is different in different sub-types of the disease and it is suggested here that this may be a consequence of the Auer rods consisting of different crystalline forms of the enzyme myeloperoxidase. There is statistical evidence to indicate that patients with Auer rods have a more favourable prognosis than those without. It is proposed that an investigation of the factors that determine the form, if any, of the crystallisation of myeloperoxidase will lead to a better understanding of the molecular events underlying the different types of AML. In the long term this may in turn lead to a therapeutic advance.
奥氏小体是仅在某些急性髓系白血病（AML）病例的白血病细胞中发现的细胞质内含物。在该疾病的不同亚型中，奥氏小体的超微结构有所不同，本文认为这可能是由于奥氏小体由髓过氧化物酶的不同晶体形式组成所致。有统计学证据表明，有奥氏小体的患者比没有奥氏小体的患者预后更好。有人提出，研究决定髓过氧化物酶结晶形式（如果有的话）的因素，将有助于更好地理解不同类型AML背后的分子事件。从长远来看，这反过来可能会带来治疗上的进展。
