Hassan H T, Rees J K
Department of Haematological Medicine, University of Cambridge Clinical School, U.K.
Pathol Res Pract. 1990 Apr;186(2):293-5. doi: 10.1016/S0344-0338(11)80547-9.
Auer bodies have been reported in several clinical studies to be the single most important favourable prognostic parameter for induction remission rate and survival duration in patients with acute myeloid leukaemia (AML). The presence of Auer bodies in 205 AML patients was studied and its relationship with five cytological and cytochemical features of leukaemic cell maturation: the presence of granules, low nuclear/cytoplasmic ratio, Sudan black positivity, esterases positivity and the maturation index was assessed in bone marrow smears of each AML patient. The results showed a significant correlation between the presence of Auer bodies and both young age and more differentiated leukaemic cells. These findings may explain their favourable prognostic significance in AML patients.
在多项临床研究中，已报道奥氏小体是急性髓系白血病（AML）患者诱导缓解率和生存期的唯一最重要的有利预后参数。对205例AML患者奥氏小体的存在情况进行了研究，并在每位AML患者的骨髓涂片中评估了其与白血病细胞成熟的五个细胞学和细胞化学特征的关系：颗粒的存在、低核质比、苏丹黑阳性、酯酶阳性和成熟指数。结果显示，奥氏小体的存在与年轻年龄和白血病细胞分化程度更高均显著相关。这些发现可能解释了它们在AML患者中的良好预后意义。
