钼和铼八面体簇合物作为X射线造影剂的前景
Prospects of molybdenum and rhenium octahedral cluster complexes as X-ray contrast agents.
作者信息
Krasilnikova Anna A, Shestopalov Michael A, Brylev Konstantin A, Kirilova Irina A, Khripko Olga P, Zubareva Kristina E, Khripko Yuri I, Podorognaya Valentina T, Shestopalova Lidiya V, Fedorov Vladimir E, Mironov Yuri V
机构信息
Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation.
Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation; Scientific Institute of Clinical and Experimental Lymphology, 2 Timakova Str., Novosibirsk 630060, Russian Federation.
出版信息
J Inorg Biochem. 2015 Mar;144:13-7. doi: 10.1016/j.jinorgbio.2014.12.016. Epub 2014 Dec 27.
Investigation of new X-ray contrast media for radiography is an important field of science since discovering of X-rays in 1895. Despite the wide diversity of available X-ray contrast media the toxicity, especially nephrotoxicity, is still a big problem to be solved. The octahedral metal-cluster complexes of the general formula [{M6Q8}L6] can be considered as quite promising candidates for the role of new radiocontrast media due to the high local concentration of heavy elements, high tuning ability of ligand environment and low toxicity. To exemplify this, the X-ray computed tomography experiments for the first time were carried out on some octahedral cluster complexes of molybdenum and rhenium. Based on the obtained data it was proposed to investigate the toxicological proprieties of cluster complex Na2H8[{Re6Se8}(P(CH2CH2CONH2)(CH2CH2COO)2)6]. Observed low cytotoxic and acute toxic effects along with rapid renal excretion of the cluster complex evidence its perspective as an X-ray contrast media for radiography.
自1895年发现X射线以来，新型X射线造影剂的研究一直是一个重要的科学领域。尽管现有X射线造影剂种类繁多，但毒性，尤其是肾毒性，仍然是一个亟待解决的大问题。通式为[{M6Q8}L6]的八面体金属簇配合物，由于其重元素的局部高浓度、配体环境的高调节能力和低毒性，可被视为新型放射性造影剂的极具潜力的候选物。为了验证这一点，首次对一些钼和铼八面体簇配合物进行了X射线计算机断层扫描实验。基于所获得的数据，建议研究簇配合物Na2H8[{Re6Se8}(P(CH2CH2CONH2)(CH2CH2COO)2)6]的毒理学性质。观察到的低细胞毒性和急性毒性作用以及簇配合物的快速肾排泄证明了其作为X射线造影剂用于放射成像的前景。
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