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学龄儿童阻塞性睡眠呼吸暂停行腺样体扁桃体切除术的并发症

Complications of adenotonsillectomy for obstructive sleep apnea in school-aged children.

作者信息

Konstantinopoulou Sofia, Gallagher Paul, Elden Lisa, Garetz Susan L, Mitchell Ron B, Redline Susan, Rosen Carol L, Katz Eliot S, Chervin Ronald D, Amin Raouf, Arens Raanan, Paruthi Shalini, Marcus Carole L

机构信息

Department of Pediatrics, Sleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States.

Biostatistics Core, The Clinical and Translational Research Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States.

出版信息

Int J Pediatr Otorhinolaryngol. 2015 Feb;79(2):240-5. doi: 10.1016/j.ijporl.2014.12.018. Epub 2014 Dec 22.

Abstract

INTRODUCTION

Adenotonsillectomy is the treatment of choice for most children with obstructive sleep apnea syndrome, but can lead to complications. Current guidelines recommend that high-risk children be hospitalized after adenotonsillectomy, but it is unclear which otherwise-healthy children will develop post-operative complications. We hypothesized that polysomnographic parameters would predict post-operative complications in children who participated in the Childhood AdenoTonsillectomy (CHAT) study.

METHODS

Children in the CHAT study aged 5-9 years with apnea hypopnea index 2-30/h or obstructive apnea index 1-20/h without comorbidities other than obesity/asthma underwent adenotonsillectomy. Associations between demographic variables and surgical complications were examined with Chi square and Fisher's exact tests. Polysomnographic parameters between subjects with/without complications were compared using Mann-Whitney tests.

RESULTS

Of the 221 children (median apnea hypopnea index 4.7/h, range 1.2-27.7/h; 31% obese), 16 (7%) children experienced complications. 3 (1.4%) children had respiratory complications including pulmonary edema, hypoxemia and bronchospasm. Thirteen (5.9%) had non-respiratory complications, including dehydration (4.5%), hemorrhage (2.3%) and fever (0.5%). There were no statistically significant associations between demographic parameters (gender, race, and obesity) or polysomnographic parameters (apnea hypopnea index, % total sleep time with SpO2<92%, SpO2 nadir, % sleep time with end-tidal CO2>50Torr) and complications.

CONCLUSIONS

This study showed a low risk of post-adenotonsillectomy complications in school-aged healthy children with obstructive apnea although many children met published criteria for admission due to obesity, or polysomnographic severity. In this specific population, none of the polysomnographic or demographic parameters predicted post-operative complications. Further research could identify the patients at greatest risk of post-operative complications.

摘要

引言

腺样体扁桃体切除术是大多数阻塞性睡眠呼吸暂停综合征患儿的首选治疗方法,但可能会导致并发症。目前的指南建议高危儿童在腺样体扁桃体切除术后住院,但尚不清楚哪些原本健康的儿童会出现术后并发症。我们假设多导睡眠图参数可以预测参与儿童腺样体扁桃体切除术(CHAT)研究的儿童的术后并发症。

方法

CHAT研究中年龄在5至9岁、呼吸暂停低通气指数为2至30次/小时或阻塞性呼吸暂停指数为1至20次/小时、除肥胖/哮喘外无其他合并症的儿童接受了腺样体扁桃体切除术。使用卡方检验和费舍尔精确检验检查人口统计学变量与手术并发症之间的关联。使用曼-惠特尼检验比较有/无并发症的受试者之间的多导睡眠图参数。

结果

在221名儿童中(中位呼吸暂停低通气指数为4.7次/小时,范围为1.2至27.7次/小时;31%为肥胖儿童),16名(7%)儿童出现并发症。3名(1.4%)儿童出现呼吸系统并发症,包括肺水肿、低氧血症和支气管痉挛。13名(5.9%)儿童出现非呼吸系统并发症,包括脱水(4.5%)、出血(2.3%)和发热(0.5%)。人口统计学参数(性别、种族和肥胖)或多导睡眠图参数(呼吸暂停低通气指数、SpO2<92%的总睡眠时间百分比、SpO2最低点、呼气末二氧化碳>50Torr的睡眠时间百分比)与并发症之间无统计学显著关联。

结论

本研究表明,患有阻塞性呼吸暂停的学龄健康儿童腺样体扁桃体切除术后并发症风险较低,尽管许多儿童因肥胖或多导睡眠图严重程度符合已公布的入院标准。在这一特定人群中,多导睡眠图或人口统计学参数均无法预测术后并发症。进一步的研究可以确定术后并发症风险最高的患者。

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