Department of Neurology, University of Missouri School of Medicine, Columbia, MO, USA.
Comprehensive Sleep Medicine Program, University of Missouri School of Medicine, Columbia, MO, USA.
Adv Exp Med Biol. 2022;1384:339-350. doi: 10.1007/978-3-031-06413-5_20.
Obstructive sleep apnea affects a large proportion of otherwise healthy children in the context of interactions between craniofacial elements, adenotonsillar hypertrophy and other anatomical factors, and neuromuscular reflexes of the upper airway. In light of the adverse consequences of sleep apnea, it is important not only to proceed with early diagnosis but also to implement adequate treatment that is guided by the pathophysiological determinants of the disease in each child. Here, we will describe the current standard of care approaches to the treatment of pediatric obstructive sleep apnea, and will also explore novel management strategies that should enable more personalized therapy in the near future.
阻塞性睡眠呼吸暂停在颅面元素、腺样体扁桃体肥大和其他解剖因素以及上呼吸道神经肌肉反射相互作用的背景下,影响了很大一部分原本健康的儿童。鉴于睡眠呼吸暂停的不良后果,不仅要及早诊断,而且要根据每个儿童疾病的病理生理决定因素进行适当的治疗,这一点非常重要。在这里,我们将描述目前治疗儿童阻塞性睡眠呼吸暂停的标准护理方法,还将探讨新的管理策略,这些策略应能在不久的将来实现更个性化的治疗。