Zegerman Philip
Department of Biochemistry, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, The Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 1QN, UK,
Chromosoma. 2015 Sep;124(3):309-21. doi: 10.1007/s00412-014-0500-y. Epub 2015 Jan 11.
A fundamental requirement for all organisms is the faithful duplication and transmission of the genetic material. Failure to accurately copy and segregate the genome during cell division leads to loss of genetic information and chromosomal abnormalities. Such genome instability is the hallmark of the earliest stages of tumour formation. Cyclin-dependent kinase (CDK) plays a vital role in regulating the duplication of the genome within the eukaryotic cell cycle. Importantly, this kinase is deregulated in many cancer types and is an emerging target of chemotherapeutics. In this review, I will consider recent advances concerning the role of CDK in replication initiation across eukaryotes. The implications for strict CDK-dependent regulation of genome duplication in the context of the cell cycle will be discussed.
所有生物体的一个基本要求是遗传物质的忠实复制和传递。在细胞分裂过程中未能准确复制和分离基因组会导致遗传信息丢失和染色体异常。这种基因组不稳定是肿瘤形成最早阶段的标志。细胞周期蛋白依赖性激酶（CDK）在真核细胞周期内调节基因组复制中起着至关重要的作用。重要的是，这种激酶在许多癌症类型中失调，并且是化疗药物的一个新兴靶点。在这篇综述中，我将探讨关于CDK在真核生物复制起始中的作用的最新进展。还将讨论在细胞周期背景下严格的CDK依赖性基因组复制调控的意义。
