Lee JunMo, Miyagishima Shin-Ya, Bhattacharya Debashish, Yoon Hwan Su
Department of Oceanography, Kyungpook National University, Daegu 41566, Korea.
Kyungpook Institute of Oceanography, Kyungpook National University, Daegu 41566, Korea.
iScience. 2024 Jun 6;27(7):110190. doi: 10.1016/j.isci.2024.110190. eCollection 2024 Jul 19.
The conserved eukaryotic functions of cell cycle genes have primarily been studied using animal/plant models and unicellular algae. Cell cycle progression and its regulatory components in red (Rhodophyta) seaweeds are poorly understood. We analyzed diurnal gene expression data to investigate the cell cycle in the red seaweed . We identified cell cycle progression and transitions in . which are induced by interactions of key regulators such as E2F/DP, RBR, cyclin-dependent kinases, and cyclins from dusk to dawn. However, several typical CDK inhibitor proteins are absent in red seaweeds. Interestingly, the G1-S transition in . is controlled by delayed transcription of . We propose that the delayed S phase entry in this seaweed may have evolved to minimize DNA damage (e.g., due to UV radiation) during replication. Our results provide important insights into cell cycle-associated physiology and its molecular mechanisms in red seaweeds.
细胞周期基因保守的真核生物功能主要是通过动物/植物模型和单细胞藻类进行研究的。对于红藻（红藻门）中细胞周期进程及其调控成分的了解还很少。我们分析了昼夜基因表达数据，以研究红藻中的细胞周期。我们在红藻中确定了细胞周期进程和转变，这些进程和转变是由关键调节因子（如E2F/DP、RBR、细胞周期蛋白依赖性激酶和细胞周期蛋白）从黄昏到黎明的相互作用诱导的。然而，红藻中不存在几种典型的细胞周期蛋白依赖性激酶抑制蛋白。有趣的是，红藻中的G1-S转变受[具体基因]延迟转录的控制。我们认为，这种海藻中S期进入的延迟可能是为了在复制过程中尽量减少DNA损伤（例如，由于紫外线辐射）而进化而来的。我们的研究结果为红藻中与细胞周期相关的生理学及其分子机制提供了重要见解。
