Posul Emrah, Yilmaz Bulent, Aktas Gulali, Kurt Mevlut
Faculty of Medicine, Department of Gastroenterology, Abant Izzet Baysal University, Golkoy, 14280, Bolu, Turkey.
Wien Klin Wochenschr. 2015 Apr;127(7-8):262-5. doi: 10.1007/s00508-014-0683-5. Epub 2015 Jan 10.
Inflammatory markers have been studied in ulcerative colitis (UC) for diagnosis, disease activity, and prediction of relapse. Blood neutrophil-to-lymphocyte (N/L) ratio has been used to determine outcomes of some malignancies and coronary artery disease. Blood N/L ratio is a simple sign of clinical inflammation. In this study, we examined N/L ratio in recurrent patients suffering from UC.
The aim of the present study was to analyze N/L ratios in serum samples of UC patients in remission and active phases. Patients' age, extend of the disease, disease duration, disease activity, drug, and other medical history were all noted for patients. C-reactive protein, erythrocyte sedimentation rate, and complete blood count were determined for patients.
Forty-nine UC patients were admitted into the present study. The blood N/L ratios were significantly increased in active phase compared with inactive UC patients (p < 0.05). The cut-off value for N/L ratio for the detection of active UC patients was calculated as ≥ 2.3 using receiver operating characteristic analysis [sensitivity: 61.2 %, specificity: 66.7 %, AUC: 0.650 (0.540-0.760), p = 0.01].
Present study shows that in patients with UC, the blood N/L ratio is associated with active disease. N/L ratio may be used as an activity parameter in UC.
炎症标志物已在溃疡性结肠炎（UC）中用于诊断、疾病活动度评估及复发预测。血液中性粒细胞与淋巴细胞（N/L）比值已被用于确定某些恶性肿瘤和冠状动脉疾病的预后。血液N/L比值是临床炎症的一个简单指标。在本研究中，我们检测了复发性UC患者的N/L比值。
本研究的目的是分析UC患者缓解期和活动期血清样本中的N/L比值。记录患者的年龄、疾病范围、病程、疾病活动度、用药情况及其他病史。测定患者的C反应蛋白、红细胞沉降率和全血细胞计数。
49例UC患者纳入本研究。与非活动期UC患者相比，活动期患者的血液N/L比值显著升高（p < 0.05）。采用受试者工作特征分析计算出检测活动期UC患者的N/L比值临界值为≥2.3[敏感性：61.2%，特异性：66.7%，曲线下面积：0.650（0.540 - 0.760），p = 0.01]。
本研究表明，在UC患者中，血液N/L比值与疾病活动相关。N/L比值可作为UC的一个活动参数。
