Johns Hopkins University School of Medicine, Baltimore, Md.
Johns Hopkins Bayview Medical Center, Baltimore, Md.
Am J Med. 2015 May;128(5):527-31. doi: 10.1016/j.amjmed.2014.11.028. Epub 2015 Jan 8.
Heart failure results in approximately 1 million hospital admissions annually in the United States and is the leading cause of 30-day readmissions.
This study explores the impact of a diuresis clinic on heart failure outcomes and cost. Data were collected prospectively on all consecutive patients who received intravenous diuretics and multidisciplinary care in the clinic from its establishment from October 2011 to December 2012, as well as a comparison cohort of patients with heart failure who were admitted to the hospital for <48 hours. The percentage of hospitalized days was calculated for both cohorts 180 days before and 180 days after each patient's index visit.
In the diuresis clinic group, 106 patients (mean age, 68.2 ± 13 years; 48% were women) were treated over 328 visits (1-22 visits per person), with a mean intravenous furosemide dose of 100 mg, average urine output of 1460 ± 730 mL, and weight loss of 2.3 ± 1.8 kg. Days hospitalized decreased from 38.3 to 31.2 per 1000 patient-days after the index diuresis clinic visit (P < .01). In the comparison group, 143 patients (mean age, 69 ± 16 years; 54% were women) were admitted for <48 hours. Days hospitalized increased from 14.4 to 21.0 per 1000 patient-days after index admission (P < .01). On multivariate analysis, the diuresis clinic was associated with 3 fewer days in the hospital per 180 days per patient, with an estimated annual savings of $12,113 per patient.
Compared with a brief hospital stay, treatment of mild decompensated heart failure in a diuresis clinic resulted in a substantial and cost-effective decline in the rate of subsequent hospitalization.
心力衰竭导致美国每年约有 100 万人住院,是 30 天再入院的主要原因。
本研究探讨了利尿诊所对心力衰竭结局和成本的影响。从 2011 年 10 月至 2012 年 12 月,该诊所建立以来,前瞻性地收集了所有接受静脉利尿剂和多学科治疗的连续患者的数据,以及心力衰竭患者入院时间<48 小时的比较队列患者的数据。计算了两个队列在每位患者指数就诊前 180 天和后 180 天的住院天数百分比。
在利尿诊所组中,106 例患者(平均年龄 68.2 ± 13 岁;48%为女性)接受了 328 次治疗(每人 1-22 次就诊),静脉注射呋塞米剂量平均为 100mg,平均尿量为 1460 ± 730ml,体重减轻 2.3 ± 1.8kg。指数利尿诊所就诊后,每 1000 名患者住院天数从 38.3 天减少到 31.2 天(P<.01)。在对照组中,143 例患者(平均年龄 69 ± 16 岁;54%为女性)入院时间<48 小时。指数入院后,每 1000 名患者住院天数从 14.4 天增加到 21.0 天(P<.01)。多变量分析显示,每 180 天每位患者住院天数减少 3 天,估计每位患者每年节省 12113 美元。
与短暂住院相比,在利尿诊所治疗轻度失代偿性心力衰竭可显著降低随后住院率,并具有成本效益。