Pradeau Catherine, Rondeau Virginie, Lévèque Emilie, Guernion Pierre-Yves, Tentillier Eric, Thicoipé Michel, Brochard Patrick
SAMU-SMUR, Département des Urgences, Centre Hospitalier Universitaire Pellegrin, place Amélie Raba Léon, 33076 Bordeaux, France.
INSERM U897-ISPED, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France.
Am J Emerg Med. 2015 Mar;33(3):367-72. doi: 10.1016/j.ajem.2014.12.007. Epub 2014 Dec 15.
The association between air pollution exposure and cardiovascular events is well established, and the effect of short-term exposure on out-of-hospital cardiac arrest (OHCA) has received some attention. The effect of air pollution exposure and the activation of mobile intensive care units (MICUs) for cardiac arrest have never been studied.
We analyzed associations between air pollutants and MICU activation for OHCA.
This is a retrospective study including 4558 patients with OHCA and MICU activation from 2007 to 2012. A time-stratified case crossover design was used. Particulate matter (PM) of median aerodynamic diameter less than 2.5 μm (PM2.5), less than 10 μm, and ozone were the 3 main pollutants used to determine the effects of pollution exposure on the event.
A daily average increase of 27.6 μg/m(3) in ozone was associated with an increase of MICU activation for OHCA the following day (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.03-1.22). For women, a daily average increase of 27.6 μg/m(3) in ozone was associated with an increase of MICU activation for OHCA the following day (OR, 1.19; 95% CI, 1.01-1.37). An hourly average increase of 10.5 μg/m(3) in PM2.5 was associated with an increase of MICU activation for OHCA in the current hour (OR, 1.11; 95% CI, 1.02-1.19). For men, an increase in PM2.5 was associated with an increase in MICU activation for OHCA the current hour (OR, 1.10; 95% CI, 1.01-1.20). No association was found with PM of median aerodynamic diameter less than 10 μm.
An association was found between air pollution and MICU activation for OHCA (ozone and PM2.5).
空气污染暴露与心血管事件之间的关联已得到充分证实，短期暴露于空气污染对院外心脏骤停（OHCA）的影响也受到了一定关注。空气污染暴露与心脏骤停时移动重症监护病房（MICU）启动之间的关系尚未得到研究。
我们分析了空气污染物与OHCA时MICU启动之间的关联。
这是一项回顾性研究，纳入了2007年至2012年间4558例发生OHCA且启动了MICU的患者。采用时间分层病例交叉设计。空气动力学直径中位数小于2.5μm的颗粒物（PM2.5）、小于10μm的颗粒物以及臭氧是用于确定污染暴露对该事件影响的3种主要污染物。
臭氧日平均浓度每增加27.6μg/m³与次日OHCA时MICU启动增加相关（比值比[OR]，1.13；95%置信区间[CI]，1.03 - 1.22）。对于女性，臭氧日平均浓度每增加27.6μg/m³与次日OHCA时MICU启动增加相关（OR，1.19；95%CI，1.01 - 1.37）。PM2.5小时平均浓度每增加10.5μg/m³与当前小时OHCA时MICU启动增加相关（OR，1.11；95%CI，1.02 - 1.19）。对于男性，PM2.5增加与当前小时OHCA时MICU启动增加相关（OR，1.10；95%CI，1.01 - 1.20）。未发现与空气动力学直径中位数小于10μm的颗粒物存在关联。
发现空气污染与OHCA时MICU启动之间存在关联（臭氧和PM2.5）。
