Morales-Cedillo Francisco, González-Solís Ariadna, Gutiérrez-Angoa Lizbeth, Cano-Ramírez Dora Luz, Gavilanes-Ruiz Marina
Dpto. de Bioquímica, Facultad de Química, Conj. E. Universidad Nacional Autónoma de México, UNAM. Cd. Universitaria, Coyoacán, 04510, Mexico, D.F., Mexico.
Plant Cell Rep. 2015 Apr;34(4):617-29. doi: 10.1007/s00299-014-1735-z. Epub 2015 Jan 11.
Several lipid classes constitute the universal matrix of the biological membranes. With their amphipathic nature, lipids not only build the continuous barrier that confers identity to every cell and organelle, but they are also active actors that modulate the activity of the proteins immersed in the lipid bilayer. The plasma membrane H(+)-ATPase, an enzyme from plant cells, is an excellent example of a transmembrane protein whose activity is influenced by the hydrophilic compartments at both sides of the membrane and by the hydrophobic domains of the lipid bilayer. As a result, an extensive documentation of the effect of numerous amphiphiles in the enzyme activity can be found. Detergents, membrane glycerolipids, and sterols can produce activation or inhibition of the enzyme activity. In some cases, these effects are associated with the lipids of the membrane bulk, but in others, a direct interaction of the lipid with the protein is involved. This review gives an account of reports related to the action of the membrane lipids on the H(+)-ATPase activity.
几种脂质类别构成了生物膜的通用基质。由于其两亲性，脂质不仅构建了赋予每个细胞和细胞器特性的连续屏障，而且还是调节嵌入脂质双层中的蛋白质活性的活跃参与者。质膜H(+) - ATP酶是植物细胞中的一种酶，是跨膜蛋白的一个绝佳例子，其活性受膜两侧亲水区域以及脂质双层疏水区域的影响。因此，可以找到大量关于众多两亲分子对该酶活性影响的文献记录。去污剂、膜甘油脂和甾醇可导致该酶活性的激活或抑制。在某些情况下，这些效应与膜主体的脂质有关，但在其他情况下，则涉及脂质与蛋白质的直接相互作用。本综述介绍了与膜脂质对H(+) - ATP酶活性作用相关的报道。
