Ariji Yoshiko, Goto Mitsuo, Fukano Hideo, Sugita Yoshihiko, Izumi Masahiro, Ariji Eiichiro
Associate Professor, Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
Assistant Professor, Department of Oral and Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Feb;119(2):246-53. doi: 10.1016/j.oooo.2014.10.021. Epub 2014 Nov 11.
To clarify the intraoral color Doppler sonographic features of tongue cancer in relation to cervical lymph node metastasis.
Thirty-one patients (24 men and 7 women; 32-87 years old; median 60.6 years) with T1-2 N0 squamous cell carcinoma of the tongue were enrolled. Preoperative clinical information and sonographic findings were collected. Patients were followed up for 2 years or more, and the presence of delayed lymph node metastasis was investigated. Significant clinical and sonographic factors were evaluated in relation to lymph node metastasis.
Significant differences in maximum and minimum tumor size, clinical type, tumor depth and thickness, shape of the invading front of the tumor, vascular index (VI) of the tumor area, and asymmetry of the VI of the deep lingual artery were observed between patients with cervical lymph node metastasis and those without. The areas under the curve (AUCs) of tumor thickness and the VI of the tumor area were 0.861 and 0.909, respectively, on receiver operating characteristic (ROC) curve analysis for predicting lymph node metastasis. The AUC for the VI showed a slightly higher value, although the difference was not significant (P = .532).
Intraoral color Doppler sonography is recommended, as it may identify predictive factors of cervical lymph node metastasis.
阐明舌癌的口腔内彩色多普勒超声特征及其与颈部淋巴结转移的关系。
纳入31例舌T1-2 N0期鳞状细胞癌患者（男性24例，女性7例；年龄32-87岁，中位年龄60.6岁）。收集术前临床信息和超声检查结果。对患者进行2年或更长时间的随访，调查是否存在延迟性淋巴结转移。评估与淋巴结转移相关的显著临床和超声因素。
颈部淋巴结转移患者与未发生转移患者在肿瘤最大和最小尺寸、临床类型、肿瘤深度和厚度、肿瘤浸润前沿形状、肿瘤区域血管指数（VI）以及舌深动脉VI不对称性方面存在显著差异。在预测淋巴结转移的受试者操作特征（ROC）曲线分析中，肿瘤厚度和肿瘤区域VI的曲线下面积（AUC）分别为0.861和0.909。VI的AUC值略高，尽管差异不显著（P = 0.532）。
建议采用口腔内彩色多普勒超声检查，因为它可能识别颈部淋巴结转移的预测因素。
