Ding Jie, Ma Hesuti, Xi Di, Qiu Hong-yi, Ye Min, Qi Jun, Bai Qiang
Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiatong University, China.
Zhonghua Nan Ke Xue. 2014 Nov;20(11):999-1003.
To investigate the association of erectile dysfunction (ED) with metabolic syndrome ( MS) and the total testosterone ( tT) level in young and middle-aged men.
This study included 154 organic ED outpatients aged 20 -59 years and 103 age-matched men with normal sexual life. We obtained their waist circumference ( WC) , blood pressure ( BP) , fasting blood glucose ( FBG) , triglyceride ( TG) , high density lipoprotein ( HDL) , tT, IIEF -5 score, erectile function indexes and other relevant variables, and compared them between the ED and non-ED groups as well as between the ED patients with MS and those without MS.
The prevalence of MS was significantly higher in the ED patients than in the non-ED males ( 40. 9 vs 17.4%, P < 0. 01). Statistically significant differences were found between the ED and non-ED groups in WC ( [90. 80 ±4. 90] vs [87. 70 ±4. 60] em, P <0.01), SBP ([134.40±14.40] vs [129.90±12.40] mmHg, P<O.OS), DBP ([86.20±7.80] vs [83.60±8.60] mmHg, P <0.05), FBG ( [5.48 ±1.02] vs [5. 11 ±0. 91] mmol, P <0. 01), HDL ( [ 1.12 ±0. 27] vs [ 1. 26 ±0. 29] mmol, P < 0. 01) , and tT ( [ 15. 98 ± 6. 55] vs [ 17. 95 ± 7. 39] mmol, P < 0. 05) , as well as between the ED patients with MS and those without MS in such erectile function indexes as tT ( [ 14.49 ±6. 23] vs [ 17.01 ±6. 60] mmol, P <0. 05), erectile penile circumference ( [9. 67 ± 1.09] vs [10.16 ± 1.01] cm, P <0. 01), erectile penile length ( [ 10.40 ± 1. 20] vs [ 10.79 ± 1. 07] cm, P <0. 05), glans temperature ( [ 31. 33 ± 0. 65] vs [ 31. 80 ± 0. 82] °C , P < 0. 01) , and mean axial hardness of the penis ( [ 332. 60 ± 137. 90] vs [ 419. 20 ± 145. 80] g, P < 0. 01 ) . WC was significantly correlated with the incidence of ED ( P < 0. 01 ) .
The prevalence of MS is significantly higher in young and middle-aged ED patients than in normal males, and MS is associated with a lower testosterone level and poorer erectile performance. Central obesity is closely correlated with ED in young and middle-aged men.
探讨中青年男性勃起功能障碍（ED）与代谢综合征（MS）及总睾酮（tT）水平之间的关联。
本研究纳入了154例年龄在20 - 59岁的器质性ED门诊患者以及103例年龄匹配的性生活正常男性。我们获取了他们的腰围（WC）、血压（BP）、空腹血糖（FBG）、甘油三酯（TG）、高密度脂蛋白（HDL）、tT、国际勃起功能指数-5（IIEF - 5）评分、勃起功能指标及其他相关变量，并在ED组与非ED组之间以及合并MS的ED患者与未合并MS的ED患者之间进行了比较。
ED患者中MS的患病率显著高于非ED男性（40.9% vs 17.4%，P < 0.01）。ED组与非ED组在WC（[90.80±4.90] vs [87.70±4.60]cm，P < 0.01）、收缩压（SBP）（[134.40±14.40] vs [129.90±12.40]mmHg，P < 0.05）、舒张压（DBP）（[86.20±7.80] vs [83.60±8.60]mmHg，P < 0.05）、FBG（[5.48±1.02] vs [5.11±0.91]mmol，P < 0.01）、HDL（[1.12±0.27] vs [1.26±0.29]mmol，P < 0.01）以及tT（[15.98±6.55] vs [17.95±7.39]mmol，P < 0.05）方面存在统计学显著差异，在合并MS的ED患者与未合并MS的ED患者之间，在tT（[14.49±6.23] vs [17.01±6.60]mmol，P < 0.05）、勃起阴茎周长（[9.67±1.09] vs [10.16±1.01]cm，P < 0.01）、勃起阴茎长度（[10.40±1.20] vs [10.79±1.07]cm，P < 0.05）、龟头温度（[31.33±0.65] vs [31.80±0.82]°C，P < 0.01）以及阴茎平均轴向硬度（[332.60±137.90] vs [419.20±145.80]g，P < 0.01）等勃起功能指标方面也存在统计学显著差异。WC与ED的发生率显著相关（P < 0.01）。
中青年ED患者中MS的患病率显著高于正常男性，且MS与较低的睾酮水平及较差的勃起功能相关。中心性肥胖与中青年男性的ED密切相关。
