Palma Elisabetta, Bufarini Celestino
City Hospital of Senigallia,Senigallia, Italy.
Int J Pharm Compd. 2014 Sep-Oct;18(5):358-64.
In 2005, the Pharmacy Department of the University Hospital of Ancona began collaboration with the engineers of the Loccioni group in order to realize a fully automated system for the preparation of cytostatic drugs, which could be safe for both healthcare workers and patients. At present, the cytotoxic laboratory of Ancona is equipped with two robots and one Class II biological-safety cabinet. The introduction of the robots in the cytotoxic laboratory has increased both efficiency and safety of the working process. The drug-preparation process begins when the pharmacist confirms the medical prescription (exact posology, modalities of reconstitution), and starts the preparation cycle. The sterility of the preparations is monthly tested in collaboration to the local microbiology laboratory. All preparations' results were germ-free even after storage at room temperature for two weeks. The dose accuracy is verified by visual and gravimetric independent systems. Drug concentration errors exceeding the limit of 10% fixed by the Italian Pharmacopeia were found only in 1.1% of the preparations. The average dose error was 0.8% (standard deviation 1.7%).
2005年，安科纳大学医院药剂科开始与洛奇奥尼集团的工程师合作，以实现一个用于制备细胞毒性药物的全自动系统，该系统对医护人员和患者都安全。目前，安科纳的细胞毒性实验室配备了两台机器人和一个二级生物安全柜。细胞毒性实验室引入机器人提高了工作流程的效率和安全性。当药剂师确认医嘱（准确的剂量、复溶方式）并启动制备周期时，药物制备过程开始。制剂的无菌性每月与当地微生物实验室合作进行检测。即使在室温下储存两周后，所有制剂的检测结果均无菌。剂量准确性通过视觉和重量独立系统进行验证。仅在1.1%的制剂中发现药物浓度误差超过意大利药典规定的10%的限度。平均剂量误差为0.8%（标准差为1.7%）。
