Gao Yu-hai, Cheng Kui, Ge Bao-Feng, Zhen Ping, Zhou Jian, Ma Xiao-Ni, Li Shao-Feng, Chen Ke-Ming
Institute of Orthopaedics, Lanzhou General Hospital of PLA, Gansu, China.
Zhongguo Gu Shang. 2014 Nov;27(11):933-7.
To investigate the effects of different-intensity sinusoidal electromagnetic fields (SEMFs) on bone mineral density (BMD) and histomorphometry in SD rats.
Thirty female SD rats were randomly divided into three groups: group A (a control group), group B (0.1 mT group) and group C (0.6 mT group). The rats in group B and C were exposed to 50 Hz SEMFs 3 hours each day. However,the magnetic intensity was different between group B and group C:0.1 mT for group B and 0.6 mT for group C. After 8 weeks, all the animals were killed. Changes of BMD and histomorphometric properties were observed.
Compared with group A, the BMD of whole body, femur and vertebrae of rats in group B increased significantly; the area percentage, number and width of bone trabeculae in vertebrae and femur of rats in group B were larger than those of group A; but the resolution of bone trabeculae of rats in group B was lower than that of group A. The trabecular number in group C rats were significantly decreased, compared with that in group A rats. The outcome of double fluorescence labeling in group B was found to be significantly different with that in group A. But the difference between rats in group A and C was not significant.
This study demonstrates that 50 Hz 0.1 mT SEMFs can increase BMD, improve bone tissue microstructure and, promote bone formation.
探讨不同强度正弦交变电磁场（SEMFs）对SD大鼠骨密度（BMD）及骨组织形态计量学的影响。
将30只雌性SD大鼠随机分为三组：A组（对照组）、B组（0.1 mT组）和C组（0.6 mT组）。B组和C组大鼠每天暴露于50 Hz的SEMFs 3小时。然而，B组和C组的磁场强度不同：B组为0.1 mT，C组为0.6 mT。8周后，处死所有动物，观察BMD及骨组织形态计量学特性的变化。
与A组相比，B组大鼠全身、股骨和椎骨的BMD显著增加；B组大鼠椎骨和股骨的骨小梁面积百分比、数量和宽度均大于A组；但B组大鼠骨小梁的清晰度低于A组。与A组大鼠相比，C组大鼠的骨小梁数量显著减少。发现B组的双荧光标记结果与A组有显著差异。但A组和C组大鼠之间的差异不显著。
本研究表明，50 Hz 0.1 mT的SEMFs可增加BMD，改善骨组织微观结构，并促进骨形成。
