Titley Heather K, Hansel Christian
Department of Neurobiology, University of Chicago, Chicago, IL, 60637, USA.
Cerebellum. 2016 Apr;15(2):87-92. doi: 10.1007/s12311-014-0635-7.
Synaptic plasticity at the parallel fiber to Purkinje cell synapse has long been considered a cellular correlate for cerebellar motor learning. Functionally, long-term depression and long-term potentiation at these synapses seem to be the reverse of each other, with both pre- and post-synaptic expression occurring in both. However, different cerebellar motor learning paradigms have been shown to be asymmetric and not equally reversible. Here, we discuss the asymmetric reversibility shown in the vestibulo-ocular reflex and eyeblink conditioning and suggest that different cellular plasticity mechanisms might be recruited under different conditions leading to unequal reversibility.
平行纤维与浦肯野细胞突触处的突触可塑性长期以来一直被认为是小脑运动学习的细胞关联因素。在功能上,这些突触处的长时程抑制和长时程增强似乎彼此相反,突触前和突触后表达在两者中均会发生。然而,已表明不同的小脑运动学习范式是不对称的且并非同等可逆。在此,我们讨论在前庭眼反射和眨眼条件反射中显示出的不对称可逆性,并提出在不同条件下可能会调用不同的细胞可塑性机制,从而导致可逆性不等。