Voges Kai, Wu Bin, Post Laura, Schonewille Martijn, De Zeeuw Chris I
Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
SINAPSE, Singapore National University, Singapore.
J Physiol. 2017 Aug 1;595(15):5301-5326. doi: 10.1113/JP274346. Epub 2017 Jul 10.
Directionality, inherent to movements, has behavioural and neuronal correlates. Direction of vestibular stimulation determines motor learning efficiency. Vestibulo-ocular reflex gain-increase correlates with Purkinje cell simple spike potentiation. The locus of neural correlates for vestibulo-ocular reflex adaptation is paradigm specific.
Compensatory eye movements elicited by head rotation, also known as vestibulo-ocular reflex (VOR), can be adapted with the use of visual feedback. The cerebellum is essential for this type of movement adaptation, although its neuronal correlates remain to be clarified. In the present study, we show that the direction of vestibular input determines the magnitude of eye movement adaptation induced by mismatched visual input in mice, with larger changes during contraversive head rotation. Moreover, the location of the neural correlate of this changed behaviour depends on the type of paradigm. Gain-increase paradigms induce increased simple spike (SS) activity in ipsilateral cerebellar Purkinje cells (PC), which is in line with eye movements triggered by optogenetic PC activation. By contrast, gain-decrease paradigms do not induce changes in SS activity, indicating that the murine vestibulo-cerebellar cortical circuitry is optimally designed to enhance ipsiversive eye movements.
运动所固有的方向性具有行为和神经元相关性。前庭刺激的方向决定运动学习效率。前庭眼反射增益增加与浦肯野细胞简单锋电位增强相关。前庭眼反射适应的神经相关性位点具有范式特异性。
头部旋转引发的代偿性眼球运动，也称为前庭眼反射（VOR），可通过视觉反馈进行适应性调节。小脑对于此类运动适应至关重要，但其神经元相关性仍有待阐明。在本研究中，我们表明前庭输入的方向决定了小鼠中由不匹配视觉输入诱导的眼球运动适应幅度，在反向头部旋转期间变化更大。此外，这种行为改变的神经相关性位置取决于范式类型。增益增加范式会诱导同侧小脑浦肯野细胞（PC）中简单锋电位（SS）活动增加，这与光遗传学激活PC触发的眼球运动一致。相比之下，增益降低范式不会诱导SS活动变化，表明小鼠前庭小脑皮质回路经过优化设计以增强同侧性眼球运动。
