Ishida M, Shinozaki H
Tokyo Metropolitan Institute of Medical Science, Japan.
Brain Res. 1988 Dec 6;474(2):386-9. doi: 10.1016/0006-8993(88)90456-8.
Excitatory actions of acromelic acid were investigated in the isolated newborn rat spinal cord. Test compounds were added to the perfusing fluid and the responses were recorded from the ventral root extracellularly. Acromelic acid caused a depolarizing response in a dose-dependent manner and the depolarizing activity of acromelic acid was superior to that of other kainoids such as kainate and domoate. The depolarization induced by acromelate was not affected by NMDA antagonists at all. Acromelic acid was proved to be one of the most potent agonists of excitatory amino acids in both vertebrates and invertebrates.
在新生大鼠离体脊髓中研究了肢端酸的兴奋作用。将测试化合物添加到灌流液中，并从腹根细胞外记录反应。肢端酸以剂量依赖的方式引起去极化反应，且肢端酸的去极化活性优于其他红藻氨酸类物质，如红藻氨酸和软骨藻酸。由肢端酸盐诱导的去极化完全不受NMDA拮抗剂的影响。事实证明，肢端酸是脊椎动物和无脊椎动物中最有效的兴奋性氨基酸激动剂之一。
